AdipoGen Life Sciences


CHF 40.00
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AG-CR1-3532-M0011 mgCHF 40.00
AG-CR1-3532-M0055 mgCHF 140.00
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Product Details
Synonyms 5 hmdC; 2'-Deoxy-5-(hydroxymethyl)-cytidine
Product Type Chemical


MW 257.2
CAS 7226-77-9
Purity Chemicals ≥98%
Appearance White solid.
Solubility Soluble in DMSO (10mg/ml) or water (5mg/ml).
Identity Determined by 1H-NMR.
Smiles O[C@H]1C[C@H](N2C=C(CO)C(N)=NC2=O)O[C@@H]1CO
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Hygroscopic.
Keep cool and dry.
Protect from moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Epigenetic base.
  • A modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA and has been used to quantify DNA hydroxymethylation levels in biological samples.
  • Enriched in the brain, suggesting a role in epigenetic control of neuronal function.
  • Used in epigenetic research and important for cancer research.
  • Potent HIV-1 reverse transcriptase activity inhibitor.
  • Can be used as building block in nucleoside and nucleotide chemistry.
Product References
  1. Interstrand cross-link formation in duplex and triplex DNA by modified pyrimidines: X. Peng, et al.; JACS 130, 10299 (2008)
  2. The nuclear DNA base, 5-hydroxymethylcytosine is present in brain and enriched in Purkinje neurons: S. Kriaucionis & N. Heintz; Science 324, 929 (2009)
  3. 5-Modified-2'-dU and 2'-dC as mutagenic anti HIV-1 proliferation agents: synthesis and activity: Y. El Sadafi, et al.; J. Med. Chem. 53, 1534 (2010)
  4. Determination of genomic 5-hydroxymethyl-2'-deoxycytidine in human DNA by capillary electrophoresis with laser induced fluorescence: A.M. Krais, et al.; Epigenetics 6, 560 (2011)
  5. Detection of oxidation products of 5-methyl-2'-deoxycytidine in Arabidopsis DNA: S. Liu, et al.; PLoS One 8, e84620 (2013)
  6. Synthesis of a DNA promoter segment containing all four epigenetic nucleosides: 5-Methyl-, 5-hydroxymethyl-, 5-formyl-, and 5-carboxy-2'-deoxycytidine: A.S. Schroeder, et al.; Angew. Chem. Int. Ed. 53, 315 (2014)
  7. Hydroxyl-radical-induced oxidation of 5-methylcytosine in isolated and cellular DNA: G.S. Madugundu, et al.; Nucleic Acids Res. 42, 7450 (2014)
  8. CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer; M. Zauri, et al.; Nature 524, 114 (2015)
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