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AdipoGen Life Sciences
SLU-PP-332
35
CHF
CHF 35.00
In stock
AG-CR1-3555-M0055 mgCHF 35.00
AG-CR1-3555-M02525 mgCHF 140.00
AG-CR1-3555-M100100 mgCHF 420.00
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| Product Details | |
|---|---|
| Synonyms | 4-Hydroxy-N′-[(E)-2-naphthylmethylene]benzohydrazide |
| Product Type | Chemical |
| Properties | |
| Formula |
C18H14N2O2 |
| MW | 290.3 |
| CAS | 303760-60-3 |
| Purity Chemicals | ≥98% |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO (5mg/ml). |
| InChi Key | RNZIMBFHRXYRLL-XDHOZWIPSA-N |
| Smiles | O=C(C1=CC=C(O)C=C1)N/N=C/C2=CC3=CC=CC=C3C=C2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
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SLU-PP-332 is a potent and selective pan-estrogen-related receptor (ERR) agonist (EC50 values are 98 nM, 230 nM and 430 nM for ERRα, ERRβ and ERRγ respectively).
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SLU-PP-332 increases energy expenditure and fatty acid oxidation, decreases fat mass, and improves insulin sensitivity. It enhances mitochondrial function and cellular respiration in skeletal muscle cell lines.
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SLU-PP-332 decreases body weight and fat mass, blood levels of total cholesterol, HDL and triglycerides and adipocyte size in a mouse model of high-fat diet-induced obesity when administered at a dose of 50 mg/kg twice per day. It reduces blood glucose levels in a glucose tolerance test in the same animals at the same dose.
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Estrogen-related receptors ERRα and ERRγ are essential regulators of cardiac metabolism. SLU-PP-332 significantly improved ejection fraction, ameliorated fibrosis and increased survival associated with pressure overload-induced heart failure (HF) without affecting cardiac hypertrophy.
Product References
- Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity: C. Billon, et al.; ACS Chem. Biol. 18, 756 (2023)
- Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney: X.X. Wang, et al.; Am. J. Pathol. 193, 1969 (2023)
- A synthetic ERR agonist alleviates metabolic syndrome: C. Billon, et al.; J. Pharmacol. Exp. Ther. 388, 232 (2024)
- Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function: W. Xu, et al.; Circulation 149, 227 (2024)