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AdipoGen Life Sciences
PP2
60
CHF
CHF 60.00
In stock
AG-CR1-3563-M0011 mgCHF 60.00
AG-CR1-3563-M0055 mgCHF 240.00
| Product Details | |
|---|---|
| Synonyms | 4-Amino-5-(4-chlorophenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine; AG 1879 |
| Product Type | Chemical |
| Properties | |
| Formula |
C15H16ClN5 |
| MW | 301.8 |
| CAS | 172889-27-9 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO. Slightly soluble in ethanol. |
| InChi Key | PBBRWFOVCUAONR-UHFFFAOYSA-N |
| Smiles | CC(C)(C)N1N=C(C2=C1N=CN=C2N)C1=CC=C(Cl)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Highly potent and selective Scr family tyrosine kinase inhibitor [1, 4, 6].
- Reduces cancer metastasis [2].
- Apoptotic [5].
- Antitumor compound [2, 3, 5].
- RIP2 inhbitor [6].
- Blocks TGF-β-mediated cellular responses [7].
- Autophagy modulator [8].
Product References
- Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation: J.H. Hanke, et al.; J. Biol. Chem. 271, 695 (1996)
- Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis: J.S. Nam, et al.; Clin. Cancer Res. 8, 2430 (2002)
- Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2): F. Carlomagno, et al.; J. Clin. Endocrinol. Metab. 88, 1897 (2003)
- The specificities of protein kinase inhibitors: an update: J. Bain, et al.; Biochem. J. 371, 199 (2003)
- Apoptotic effect of PP2 a Src tyrosine kinase inhibitor, in murine B cell leukemia: M. Lee, et al.; J. Cell Biochem. 93, 629 (2004)
- The selectivity of protein kinase inhibitors: a further update: J. Bain, et al.; Biochem. J. 408, 297 (2007)
- The Src family kinase inhibitors PP2 and PP1 block TGF-beta1-mediated cellular responses by direct and differential inhibition of type I and type II TGF-beta receptors: H. Ungefroren, et al.; Curr. Cancer Drug Targets 11, 524 (2011)
- Suppression of autophagy sensitizes multidrug resistant cells towards Src tyrosine kinase specific inhibitor PP2: J.H. Ahn & M. Lee; Cancer Lett. 310, 188 (2011)
- The NLRP3 Inammasome Works as a Sensor for Detecting Hypoactivity of the Mitochondrial Src Family Kinases: Y. Sekiguchi, et al.; J. Immunol. ahead of print (2023)
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