AdipoGen Life Sciences


CHF 60.00
In stock
AG-CR1-3563-M0011 mgCHF 60.00
AG-CR1-3563-M0055 mgCHF 240.00
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Product Details
Synonyms 4-Amino-5-(4-chlorophenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine; AG 1879
Product Type Chemical


MW 301.8
CAS 172889-27-9
Purity Chemicals ≥98% (HPLC)
Appearance White solid.
Solubility Soluble in DMSO. Slightly soluble in ethanol.
Smiles CC(C)(C)N1N=C(C2=C1N=CN=C2N)C1=CC=C(Cl)C=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF
  • Highly potent and selective Scr family tyrosine kinase inhibitor [1, 4, 6].
  • Reduces cancer metastasis [2].
  • Apoptotic [5].
  • Antitumor compound [2, 3, 5].
  • RIP2 inhbitor [6].
  • Blocks TGF-β-mediated cellular responses [7].
  • Autophagy modulator [8].
Product References
  1. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation: J.H. Hanke, et al.; J. Biol. Chem. 271, 695 (1996)
  2. Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis: J.S. Nam, et al.; Clin. Cancer Res. 8, 2430 (2002)
  3. Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2): F. Carlomagno, et al.; J. Clin. Endocrinol. Metab. 88, 1897 (2003)
  4. The specificities of protein kinase inhibitors: an update: J. Bain, et al.; Biochem. J. 371, 199 (2003)
  5. Apoptotic effect of PP2 a Src tyrosine kinase inhibitor, in murine B cell leukemia: M. Lee, et al.; J. Cell Biochem. 93, 629 (2004)
  6. The selectivity of protein kinase inhibitors: a further update: J. Bain, et al.; Biochem. J. 408, 297 (2007)
  7. The Src family kinase inhibitors PP2 and PP1 block TGF-beta1-mediated cellular responses by direct and differential inhibition of type I and type II TGF-beta receptors: H. Ungefroren, et al.; Curr. Cancer Drug Targets 11, 524 (2011)
  8. Suppression of autophagy sensitizes multidrug resistant cells towards Src tyrosine kinase specific inhibitor PP2: J.H. Ahn & M. Lee; Cancer Lett. 310, 188 (2011)
  9. The NLRP3 Inammasome Works as a Sensor for Detecting Hypoactivity of the Mitochondrial Src Family Kinases: Y. Sekiguchi, et al.; J. Immunol. ahead of print (2023)
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