AdipoGen Life Sciences


CHF 30.00
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AG-CR1-3566-M01010 mgCHF 30.00
AG-CR1-3566-M05050 mgCHF 80.00
AG-CR1-3566-M250250 mgCHF 240.00
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Product Details
Synonyms Pirinixic acid; NSC 310038; BRN 0759945; ((4-Chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio) acetic acid
Product Type Chemical


MW 323.8
CAS 50892-23-4
RTECS AG2915000
Purity Chemicals ≥98%
Appearance Off-white solid.
Solubility Soluble in ethanol, DMSO, dimethyl formamide or PBS (pH 7.2).
Smiles CC1=CC=CC(NC2=NC(SCC(O)=O)=NC(Cl)=C2)=C1C
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Potent peroxisome proliferator-activated receptor (PPARα) activator [1, 2, 7, 9]. Activates also PPARγ [4, 7] but not PPARδ [8].
  • Potent anti-hypercholesterolemic agent [1].
  • Hypolipidemic compound. Lipogenesis inducer [2, 10].
  • Tumor promoter [2, 3, 5, 15].
  • Causes increased cell proliferation and decreased apoptosis [5].
  • Anti-inflammatory. Inhibits NF-κB transcriptional activity and decreases the inflammatory response by reducing the production of inflammatory cytokines (TNF-α, IL1β). Reduces oxidative stress [6, 7, 12, 13].
  • Increases fatty acid oxidation [11].
  • Directly affects insulin signaling. Increases glucose uptake [12].
  • Enhancer of ethanol metabolism.
  • Reviews [5, 11, 14].
Product References
  1. A potent antihypercholesterolemic agent: (4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio) acetic acid (Wy-14643): A.A. Santilli, et al.; Experientia 30, 1110 (1974)
  2. The hepatic effects of hypolipidemic drugs (clofibrate, nafenopin, tibric acid, and Wy-14,643) on hepatic peroxisomes and peroxisome-associated enzymes: D.E. Moody & J.K. Reddy; Am. J. Pathol. 90, 435 (1978)
  3. Peroxisome proliferation and hepatocarcinogenesis: M.S. Rao & J.K. Reddy; Carcinogenesis 8, 631 (1987)
  4. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids: A. Schmidt, et al.; Mol. Endocrinol. 6, 1634 (1992)
  5. Non-genotoxic hepatocarcinogenesis: suppression of apoptosis by peroxisome proliferators: R.A. Roberts; Ann. N. Y. Acad. Sci. 804, 588 (1996) (Review)
  6. The PPARα-leukotriene B4 pathway to inflammation control: P.R. Devchand, et al.; Nature 384, 39 (1996)
  7. Peroxisome proliferator-activated receptors a and g are activated by indomethacin and other non-steroidal anti-inflammatory drugs: J.M. Lehmann, et al.; J. Biol. Chem. 272, 3406 (1997)
  8. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta: B.M. Forman, et al.; PNAS 94, 4312 (1997)
  9. Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators: B. Staels, et al.; Nature 393, 790 (1998)
  10. Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48: D. Lindén, et al.; J. Biol. Chem. 277, 23044 (2002)
  11. Peroxisome proliferator-activated receptor alpha (PPARalpha) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart: B.N. Finck & D.P. Kelly; J. Mol. Cell Cardiol. 34, 1249 (2002) (Review)
  12. WY-14643 and 9- cis-retinoic acid induce IRS-2/PI 3-kinase signalling pathway and increase glucose transport in human skeletal muscle cells: differential effect in myotubes from healthy subjects and Type 2 diabetic patients: K. Bouzakri, et al.; Diabetologia 47, 1314 (2004)
  13. Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: effects of the PPAR-alpha agonist WY14643: M. Collino, et al.; Free Radic. Biol. Med. 41, 579 (2006)
  14. Cardiovascular actions of the peroxisome proliferator-activated receptor-alpha (PPARalpha) agonist Wy14,643: P. Zahradka; Cardiovasc. Drug Rev. 25, 99 (2007) (Review)
  15. PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators; F.J. Gonzalez & Y.M. Shah; Toxicology 246, 2 (2008)
  16. PPARα agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase: X. Chen, et al.; Free Radic. Biol. Med. 169, 283 (2021)
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