AdipoGen Life Sciences


CHF 70.00
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AG-CR1-3579-M01010 mgCHF 70.00
AG-CR1-3579-M05050 mgCHF 280.00
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Product Details
Synonyms 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid; AA 673; Amoxanox; CHX 3673
Product Type Chemical


MW 298.3
CAS 68302-57-8
Purity Chemicals ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in DMSO (10mg/ml) or dimethylformamide (15mg/ml). Insoluble in water.
Smiles CC(C)C1=CC2=C(OC3=C(C=C(C(O)=O)C(N)=N3)C2=O)C=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Antiallergic [1,2].
  • Anti-inflammatory [2].
  • Antagonizes the angiogenic and mitogenic activity of FGF-1 through S100A13. Inhibits FGF-1 release [3, 5].
  • Binds to HSP90. Inhibits C-terminal chaperone activity [4].
  • Induces an increase in nonsense-containing mRNAs amount in treated cells, leading to the synthesis of functional full-length proteins in an efficient manner [6].
  • Selective inhibitor of TANK-binding Kinase 1 (TBK1) and IKKε. Reversibly lowers weight and improves insulin sensitivity and reduces inflammation and attenuated hepatic steatosis in obese mices without affecting food intake [7].
Product References
  1. Inhibition by amoxanox (AA-673) of the immunologically, leukotriene D4- or platelet-activating factor-stimulated bronchoconstriction in guinea pigs and rats: T. Saijo, et al.; Int. Arch. Allergy Appl. Immunol. 77, 315 (1985)
  2. Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase: H. Makino, et al.; Int. Arch. Allergy Appl. Immunol. 82, 66 (1987)
  3. Amlexanox reversibly inhibits cell migration and proliferation and induces the Src-dependent disassembly of actin stress fibers in vitro: M. Landriscina, et al.; J. Biol. Chem. 275, 32753 (2000)
  4. Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox: M. Okada, et al.; Biochem. J. 374, 433 (2003)
  5. Molecular level interactions of S100A13 with amlexanox: inhibitor for formation of the multiprotein complex in the nonclassical pathway of acidic fibroblast growth factor: S.G. Rani, et al.; Biochemistry 49, 2585 (2010)
  6. Rescue of nonsense mutations by amlexanox in human cells: S. Gonzalez-Hilarion, et al.; Orphanet. J. Rare Dis. 7, 58 (2012)
  7. An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice: S.M. Reilly, et al.; Nat. Med. 19, 313 (2013)
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