Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
Amlexanox
70
CHF
CHF 70.00
In stock
AG-CR1-3579-M01010 mgCHF 70.00
AG-CR1-3579-M05050 mgCHF 280.00
| Product Details | |
|---|---|
| Synonyms | 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid; AA 673; Amoxanox; CHX 3673 |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H14N2O4 |
| MW | 298.3 |
| CAS | 68302-57-8 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO (10mg/ml) or dimethylformamide (15mg/ml). Insoluble in water. |
| InChi Key | SGRYPYWGNKJSDL-UHFFFAOYSA-N |
| Smiles | CC(C)C1=CC2=C(OC3=C(C=C(C(O)=O)C(N)=N3)C2=O)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antiallergic [1,2].
- Anti-inflammatory [2].
- Antagonizes the angiogenic and mitogenic activity of FGF-1 through S100A13. Inhibits FGF-1 release [3, 5].
- Binds to HSP90. Inhibits C-terminal chaperone activity [4].
- Induces an increase in nonsense-containing mRNAs amount in treated cells, leading to the synthesis of functional full-length proteins in an efficient manner [6].
- Selective inhibitor of TANK-binding Kinase 1 (TBK1) and IKKε. Reversibly lowers weight and improves insulin sensitivity and reduces inflammation and attenuated hepatic steatosis in obese mices without affecting food intake [7].
Product References
- Inhibition by amoxanox (AA-673) of the immunologically, leukotriene D4- or platelet-activating factor-stimulated bronchoconstriction in guinea pigs and rats: T. Saijo, et al.; Int. Arch. Allergy Appl. Immunol. 77, 315 (1985)
- Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase: H. Makino, et al.; Int. Arch. Allergy Appl. Immunol. 82, 66 (1987)
- Amlexanox reversibly inhibits cell migration and proliferation and induces the Src-dependent disassembly of actin stress fibers in vitro: M. Landriscina, et al.; J. Biol. Chem. 275, 32753 (2000)
- Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox: M. Okada, et al.; Biochem. J. 374, 433 (2003)
- Molecular level interactions of S100A13 with amlexanox: inhibitor for formation of the multiprotein complex in the nonclassical pathway of acidic fibroblast growth factor: S.G. Rani, et al.; Biochemistry 49, 2585 (2010)
- Rescue of nonsense mutations by amlexanox in human cells: S. Gonzalez-Hilarion, et al.; Orphanet. J. Rare Dis. 7, 58 (2012)
- An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice: S.M. Reilly, et al.; Nat. Med. 19, 313 (2013)
Related Products
