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AdipoGen Life Sciences
Melanin Production Inhibitor A3B5
170
CHF
CHF 170.00
In stock
AG-CR1-3605-M0011 mgCHF 170.00
| Product Details | |
|---|---|
| Synonyms | N-(3,5-Dimethylphenyl)-3-methoxybenzamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H17NO2 |
| MW | 255.3 |
| CAS | 346721-60-6 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO or methanol. Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| InChi Key | YOYXSQKGMBWPGK-UHFFFAOYSA-N |
| Smiles | COC1=CC(=CC=C1)C(=O)NC1=CC(C)=CC(C)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Non-cytotoxic melanogenesis inhibitor. Potential depigmentation agent.
- Tyrosinase-related protein 2 (TRP-2) expression inhibitor, via proteasomal degradation.
- Inhibits the proliferation of melanocytes and melanoma cells through cell cycle arrest in G1.
- Moderate skin tumor growth suppressor in vivo.
Product References
- Identification of a potent and noncytotoxic inhibitor of melanin production: S. Hwang, et al.; Bioorg. Med. Chem. 18, 5602 (2010)
- N-(3,5-dimethylphenyl)-3-methoxybenzamide (A(3)B(5)) targets TRP-2 and inhibits melanogenesis and melanoma growth: E.J. Lee, et al.; J. Invest. Dermatol. 131, 1701 (2011)
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