Melanin Production Inhibitor A<sub>3</sub>B<sub>5</sub>

More Information
Product Details
Synonyms	N-(3,5-Dimethylphenyl)-3-methoxybenzamide
Product Type	Chemical
Properties
Formula	C₁₆H₁₇NO₂
MW	255.3
CAS	346721-60-6
Purity Chemicals	≥98% (NMR)
Appearance	White solid.
Solubility	Soluble in DMSO or methanol. Insoluble in water.
Identity	Determined by ¹H-NMR.
InChi Key	YOYXSQKGMBWPGK-UHFFFAOYSA-N
Smiles	COC1=CC(=CC=C1)C(=O)NC1=CC(C)=CC(C)=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Non-cytotoxic melanogenesis inhibitor. Potential depigmentation agent.
Tyrosinase-related protein 2 (TRP-2) expression inhibitor, via proteasomal degradation.
Inhibits the proliferation of melanocytes and melanoma cells through cell cycle arrest in G1.
Moderate skin tumor growth suppressor in vivo.

Product References

Identification of a potent and noncytotoxic inhibitor of melanin production: S. Hwang, et al.; Bioorg. Med. Chem. 18, 5602 (2010)
N-(3,5-dimethylphenyl)-3-methoxybenzamide (A(3)B(5)) targets TRP-2 and inhibits melanogenesis and melanoma growth: E.J. Lee, et al.; J. Invest. Dermatol. 131, 1701 (2011)

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Melanin Production Inhibitor A3B5