Melanin Production Inhibitor A3B5

CHF 170.00
In stock
AG-CR1-3605-M0011 mgCHF 170.00
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Product Details
Synonyms N-(3,5-Dimethylphenyl)-3-methoxybenzamide
Product Type Chemical
Properties
Formula

C16H17NO2

MW 255.3
CAS 346721-60-6
Purity Chemicals ≥98% (NMR)
Appearance White solid.
Solubility Soluble in DMSO or methanol. Insoluble in water.
Identity Determined by 1H-NMR.
InChi Key YOYXSQKGMBWPGK-UHFFFAOYSA-N
Smiles COC1=CC(=CC=C1)C(=O)NC1=CC(C)=CC(C)=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Non-cytotoxic melanogenesis inhibitor. Potential depigmentation agent.
  • Tyrosinase-related protein 2 (TRP-2) expression inhibitor, via proteasomal degradation.
  • Inhibits the proliferation of melanocytes and melanoma cells through cell cycle arrest in G1.
  • Moderate skin tumor growth suppressor in vivo.
Product References
  1. Identification of a potent and noncytotoxic inhibitor of melanin production: S. Hwang, et al.; Bioorg. Med. Chem. 18, 5602 (2010)
  2. N-(3,5-dimethylphenyl)-3-methoxybenzamide (A(3)B(5)) targets TRP-2 and inhibits melanogenesis and melanoma growth: E.J. Lee, et al.; J. Invest. Dermatol. 131, 1701 (2011)
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