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AdipoGen Life Sciences
AEBSF . hydrochloride
50
CHF
CHF 50.00
In stock
AG-CR1-3610-M05050 mgCHF 50.00
AG-CR1-3610-M250250 mgCHF 120.00
AG-CR1-3610-G0011 gCHF 250.00
| Product Details | |
|---|---|
| Synonyms | 4-(2-Aminoethyl)benzenesulfonylfluoride; Pefabloc SC |
| Product Type | Chemical |
| Properties | |
| Formula |
C8H10FNO2S . HCl |
| MW | 203.2 . 36.5 |
| CAS | 30827-99-7 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White solid. |
| Solubility | Soluble in water or 100% ethanol. |
| InChi Key | WRDABNWSWOHGMS-UHFFFAOYSA-N |
| Smiles | [Cl-].[NH3+]CCC1=CC=C(C=C1)S(F)(=O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Water soluble, irreversible serine protease (chymotrypsin, kallikrein, plasmin, thrombin and trypsin) inhibitor. Stable, non-toxic alternative to PMSF.
- Potent, selective inhibitor of Site-1-protease (S1P).
- Used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation by selectively inhibiting S1P.
- NAD(P)H oxidase inhibitor.
- Inhibits activation of TGFβ and activates JNK and p38 MAP kinases.
- β-Secretase inhibitor. Shown to inhibit β-amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations.
Product References
- Irreversible enzyme inhibitors. 180. Irreversible inhibitors of the Cla component of complement derived from m-(phenoxypropoxy)benzamidine and phenoxyacetamide: B.R. Baker & M. Cory; J. Med. Chem. 14, 119 (1971)
- Synthetic low molecular weight inhibitors of serum kallikrein: F. Markwardt, et al.; Biochem. Pharmacol. 23, 2247 (1974)
- Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF: M. Citron, et al.; Neuron 17, 171 (1996)
- Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds: V. Diatchuk, et al.; J. Biol. Chem. 272, 13292 (1997)
- 4-(2-Aminoethyl)benzenesulfonyl fluoride attenuates tumor-necrosis-factor-alpha-induced blood-brain barrier opening: P. Megyeri, et al.; Eur. J. Pharmacol. 374, 207 (1999)
- Irreversible inhibitors of serine, cysteine, and threonine proteases: J.C. Powers, et al.; Chem. Rev. 102, 4639 (2002)
- A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6: T. Okada, et al.; J. Biol. Chem. 278, 31024 (2003)
- Proteolytic activation of latent TGF-beta precedes caspase-3 activation and enhances apoptotic death of lung epithelial cells: V.T. Solovyan & J. Keski-Oja; J. Cell Physiol. 207, 445 (2006)
- Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease: S. Saw, et al.; PLoS One 7, e41107 (2012)
- Natto extract, a Japanese fermented soybean food, directly inhibits viral infections including SARS-CoV-2 in vitro: M. Oba, et al.; BBRC 570, 21 (2021)
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