Carbamoylcholine . chloride

CHF 45.00
In stock
AG-CR1-3649-M100100 mgCHF 45.00
AG-CR1-3649-G0011 gCHF 90.00
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Product Details
Synonyms Carbachol; (2-Hydroxyethyl)trimethylammonium chloride carbamate
Product Type Chemical
Properties
Formula

C6H15N2O2 . Cl

MW 147.3 . 35.4
CAS 51-83-2
RTECS GA0875000
Purity Chemicals ≥98%
Appearance White to yellow crystalline solid.
Solubility Soluble in water, methanol, ethanol or DMSO.
InChi Key AIXAANGOTKPUOY-UHFFFAOYSA-N
Smiles NC(OCC[N+](C)(C)C)=O.[Cl-]
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Hygroscopic.
Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Acetylcholine analog that activates acetylcholine receptors (AChR).
  • Non-selective agonist of nicotinic (nAChR) and muscarinic (mAChR) receptors that is resistant to the action of cholinesterases.
  • Used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility and neuronal signaling.
  • Shown to inhibit apoptotic death of cultured neurons.
Product References
  1. Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons: G.M. Yan, et al.; Mol. Pharmacol. 47, 248 (1995)
  2. Carbamoylcholine homologs: Novel and potent agonists at neuronal nicotinic acetylcholine receptors: A.A. Jensen, et al.; Mol. Pharmacol. 64, 865 (2003)
  3. The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells: Y. Xiao & K.J. Kellar; J. Pharmacol. Exp. Ther. 310, 98 (2004)
  4. Distinct pathways of ERK activation by the muscarinic agonists pilocarpine and carbachol in a human salivary cell line: A.L. Lin, et al.; Am. J. Physiol. Cell Physiol. 294, C1454 (2008)
  5. K+ACh channel activation with carbachol increases atrial ANP release: D.Y. Xu, et al.; Life Sci. 82, 1083 (2008)
  6. IL-17A induces hypo-contraction of intestinal smooth muscle via induction of iNOS in muscularis macrophages: D. Mori, et al.; J. Pharmacol. Sci. 125, 394 (2014)
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