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AdipoGen Life Sciences
Carbamoylcholine . chloride
45
CHF
CHF 45.00
In stock
AG-CR1-3649-M100100 mgCHF 45.00
AG-CR1-3649-G0011 gCHF 95.00
| Product Details | |
|---|---|
| Synonyms | Carbachol; (2-Hydroxyethyl)trimethylammonium chloride carbamate |
| Product Type | Chemical |
| Properties | |
| Formula |
C6H15N2O2 . Cl |
| MW | 147.3 . 35.4 |
| CAS | 51-83-2 |
| RTECS | GA0875000 |
| Purity Chemicals | ≥98% |
| Appearance | White to yellow crystalline solid. |
| Solubility | Soluble in water, methanol, ethanol or DMSO. |
| InChi Key | AIXAANGOTKPUOY-UHFFFAOYSA-N |
| Smiles | NC(OCC[N+](C)(C)C)=O.[Cl-] |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Hygroscopic. Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Acetylcholine analog that activates acetylcholine receptors (AChR).
- Non-selective agonist of nicotinic (nAChR) and muscarinic (mAChR) receptors that is resistant to the action of cholinesterases.
- Used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility and neuronal signaling.
- Shown to inhibit apoptotic death of cultured neurons.
Product References
- Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons: G.M. Yan, et al.; Mol. Pharmacol. 47, 248 (1995)
- Carbamoylcholine homologs: Novel and potent agonists at neuronal nicotinic acetylcholine receptors: A.A. Jensen, et al.; Mol. Pharmacol. 64, 865 (2003)
- The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells: Y. Xiao & K.J. Kellar; J. Pharmacol. Exp. Ther. 310, 98 (2004)
- Distinct pathways of ERK activation by the muscarinic agonists pilocarpine and carbachol in a human salivary cell line: A.L. Lin, et al.; Am. J. Physiol. Cell Physiol. 294, C1454 (2008)
- K+ACh channel activation with carbachol increases atrial ANP release: D.Y. Xu, et al.; Life Sci. 82, 1083 (2008)
- IL-17A induces hypo-contraction of intestinal smooth muscle via induction of iNOS in muscularis macrophages: D. Mori, et al.; J. Pharmacol. Sci. 125, 394 (2014)
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