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AdipoGen Life Sciences
RF-22c [5-Lipoxygenase Inhibitor]
145
CHF
CHF 145.00
In stock
AG-CR1-3653-M0022 mgCHF 145.00
| Product Details | |
|---|---|
| Synonyms | 3-Dodecyl-4,5-dimethoxy-3,5-cyclohexadiene-1,2-dione; 5-LO Inhibitor RF-22c |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H32O4 |
| MW | 336.5 |
| CAS | 1680206-61-4 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Orange solid. |
| Solubility | Soluble in DMSO (1mg/ml), ethanol or chloroform. Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Other Product Data |
Stock solutions (1mg/ml) are stable up to 1 month when stored at -20°C. |
| InChi Key | ROJYDZSFBXLWIR-UHFFFAOYSA-N |
| Smiles | CCCCCCCCCCCCC(C1=O)=C(OC)C(OC)=CC1=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Selective and reversible potent inhibitor of human 5-lipoxygenase (5-LO). This enzyme catalyzes two initial steps in the conversion of arachidonic acid into leukotrienes, well known mediators of inflammatory and allergic reactions.
- Potently inhibits 5-LO product synthesis intact human leukocytes, such as neutrophils and monocytes (IC50≥22nM) and in cell-free assays (IC50≥140nM) without affecting 12/15-LOs, cyclooxygenase (COX)-1/2 or arachidonic acid release.
- Anti-inflammatory compound. Shows pronounced effectiveness in different models of inflammation in vivo at 0.1 mg/kg; i.p. Impaired (I) bronchoconstriction in ovalbumin-sensitized mice challenged with acetylcholine, (II) exudate formation in carrageenan-induced paw edema and (III) zymosan-induced leukocyte infiltration in air pouches.
Product References
- Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes: R. Filosa, et al.; Eur. J. Med. Chem. 94, 132 (2015)
- The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo: A.M. Schaible, et al.; Biochem. Pharmacol. 112, 60 (2016)
- Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase: A. Peduto, et al.; Eur. J. Med. Chem. 127, 715 (2017)
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