AdipoGen Life Sciences

Myxochelin A

Name: Myxochelin A
Brand: AdipoGen Life Sciences
SKU: AG-CN2-0470
Price: 420.00 CHF
Availability: InStock

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AG-CN2-0470-C100100 µgCHF 120.00

AG-CN2-0470-M0011 mgCHF 420.00

Specifications / Handling

More Information
Product Details
Synonyms	(S)-N,N'-(6-Hydroxyhexane-1,5-diyl)bis(2,3-dihydroxybenzamide)
Product Type	Chemical
Properties
Formula	C₂₀H₂₄N₂O₇
MW	404.4
CAS	120243-02-9
Source/Host Chemicals	Synthetic. Originally isolated from Pyxidicoccus fallax HKI 727.
Purity Chemicals	≥99% (NMR)
Appearance	Solid.
Solubility	Soluble in DMSO, ethanol, methanol, acetone, ethylacetate or chloroform. Insoluble in water or hexane.
Identity	Determined by ¹H-NMR.
InChi Key	WNBVGSNESTZACV-LBPRGKRZSA-N
Smiles	OC[C@H](CCCCNC(=O)C1=C(O)C(O)=CC=C1)NC(=O)C1=CC=CC(O)=C1O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C. Stable for at least 1 year after receipt when stored at +4°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product Description

Potent inhibitor of human 5-lipoxygenase (5-LO). This enzyme catalyzes two initial steps in the conversion of arachidonic acid into leukotrienes, well known mediators of inflammatory and allergic reactions.
Iron-chelating compound.
Anticancer antibiotic. Shown to inhibit tumor cell invasion in vitro.
Antibacterial compound.
Antioxidant with free radical scavenging activities.

Product-specific References

Myxochelin A, a new iron-chelating compound from Angiococcus disciformis (Myxobacterales). Production, isolation, physico-chemical and biological properties: B. Kunze, et al.; J. Antibiot. 42, 14 (1989)
Myxochelin A, a cytotoxic antibiotic from the myxobacterium Angiococcus disciformis: J.W. Ahn, et al.; OPEM 2, 64 (2001)
Antioxidative and free radical scavenging activities of Myxochelin A isolated from Angiococcus sp.(Myxobacteria): H.-H. Lee, et al.; Food Sci. Biotech. 11, 184 (2002)
Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861: S. Miyanaga, et al.; J. Antibiot. 59, 698 (2006)
Synthesis and evaluation of myxochelin analogues as antimetastatic agents: S. Miyanaga, et al.; Bioorg. Med. Chem. 17, 2724 (2009)
Myxochelins target human 5-lipoxygenase: S. Schieferdecker, et al.; J. Nat. Prod. 78, 335 (2015)
Harnessing enzymatic promiscuity in Myxochelin biosynthesis for the production of 5-Lipoxygenase inhibitors: J. Korp, et al.; Chembiochem. 16, 2445 (2015)

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