ID-8

CHF 30.00
In stock
AG-CR1-3655-M0011 mgCHF 30.00
AG-CR1-3655-M0055 mgCHF 65.00
AG-CR1-3655-M02525 mgCHF 260.00
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Product Details
Synonyms 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
Product Type Chemical
Properties
Formula

C16H14N2O4

MW 298.3
CAS 147591-46-6
Purity Chemicals ≥98% (1H-NMR)
Appearance Solid.
Solubility Soluble in DMSO (25mg/ml) and DMF (30mg/ml).
InChi Key VVZNWYXIOADGSW-UHFFFAOYSA-N
Smiles CC1=C([N+]([O-])=O)C2=CC=C(O)C=C2N1C3=CC=C(OC)C=C3
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Cell culture supplement that can sustain self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. At 10μM it stimulates proliferation in serum-free media at a steady rate for more than 30 days. 
  • Reversibly maintains the long-term culture of ESCs by sustaining Nanog gene expression through Sox2-Oct3/4 activation and enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs (DYRK2 and DYRK4).
Product References
  1. Indole derivatives sustain embryonic stem cell self-renewal in long-term culture: T. Miyabayashi, et al.; Biosci. Biotechnol. Biochem. 72, 1242 (2008)
  2. Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion: K. Hasegawa, et al.; Stem Cells Transl. Med. 1, 18 (2012)
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