ID-8 | CAS 147591-46-6 - Order from AdipoGen

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Product Details
Synonyms	1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
Product Type	Chemical
Properties
Formula	C₁₆H₁₄N₂O₄
MW	298.3
CAS	147591-46-6
Purity Chemicals	≥98% (¹H-NMR)
Appearance	Solid.
Solubility	Soluble in DMSO (25mg/ml) and DMF (30mg/ml).
InChi Key	VVZNWYXIOADGSW-UHFFFAOYSA-N
Smiles	CC1=C([N+]([O-])=O)C2=CC=C(O)C=C2N1C3=CC=C(OC)C=C3
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Cell culture supplement that can sustain self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. At 10μM it stimulates proliferation in serum-free media at a steady rate for more than 30 days.
Reversibly maintains the long-term culture of ESCs by sustaining Nanog gene expression through Sox2-Oct3/4 activation and enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs (DYRK2 and DYRK4).

Product References

Indole derivatives sustain embryonic stem cell self-renewal in long-term culture: T. Miyabayashi, et al.; Biosci. Biotechnol. Biochem. 72, 1242 (2008)
Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion: K. Hasegawa, et al.; Stem Cells Transl. Med. 1, 18 (2012)
Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases: M.F. Lindberg, et al.; J. Med. Chem. ahead of print (2023)

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