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AdipoGen Life Sciences
TG007
95
CHF
CHF 95.00
In stock
AG-CR1-3666-M0055 mgCHF 95.00
| Product Details | |
|---|---|
| Synonyms | (Z)-3-Ethyl-2-(2-oxopropylidene)-2,3-dihydrobenzo[d]thiazol-5-yl acetate; ProINDY |
| Product Type | Chemical |
| Properties | |
| Formula |
C14H15NO3S |
| MW | 277.3 |
| CAS | 719277-30-2 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| InChi Key | RLEOCVDWLAYGRX-AUWJEWJLSA-N |
| Smiles | O=C(C)/C=C1SC2=CC=C(OC(C)=O)C=C2N\1CC |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Prodrug form (acetylated derivative) of INDY (Prod. No. AG-CR1-3665).
- Cell permeable ATP-competitive DYRK1A and DYRK1B inhibitor.
- Inhibits phosphorylation of Tau-protein and rescues repressed calcineurin/NFAT signaling.
- Recovers Xenopus embryos from head malformation induced by DYRK1A overexpression in vivo.
Product References
- Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A: Y. Ogawa, et al.; Nat. Commun. 1, 86 (2010)
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