TG007

CHF 95.00
In stock
AG-CR1-3666-M0055 mgCHF 95.00
AG-CR1-3666-M02525 mgCHF 380.00
More Information
Product Details
Synonyms (Z)-3-Ethyl-2-(2-oxopropylidene)-2,3-dihydrobenzo[d]thiazol-5-yl acetate; ProINDY
Product Type Chemical
Properties
Formula

C14H15NO3S

MW 277.3
CAS 719277-30-2
Purity Chemicals ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in DMSO (10mg/ml).
Identity Determined by 1H-NMR.
InChi Key RLEOCVDWLAYGRX-AUWJEWJLSA-N
Smiles O=C(C)/C=C1SC2=CC=C(OC(C)=O)C=C2N\1CC
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Prodrug form (acetylated derivative) of INDY (Prod. No. AG-CR1-3665).
  • Cell permeable ATP-competitive DYRK1A and DYRK1B inhibitor.
  • Inhibits phosphorylation of Tau-protein and rescues repressed calcineurin/NFAT signaling.
  • Recovers Xenopus embryos from head malformation induced by DYRK1A overexpression in vivo.
Product References
  1. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A: Y. Ogawa, et al.; Nat. Commun. 1, 86 (2010)
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