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AdipoGen Life Sciences
3-Bromopyruvic acid
45
CHF
CHF 45.00
In stock
AG-CR1-3682-G0011 gCHF 45.00
AG-CR1-3682-G0055 gCHF 95.00
| Product Details | |
|---|---|
| Synonyms | 3-Bromopyruvate; 3-Bromo-2-oxopropionic acid; 3-BrPA |
| Product Type | Chemical |
| Properties | |
| Formula |
C3H3BrO3 |
| MW | 167.0 |
| CAS | 1113-59-3 |
| RTECS | UZ0840000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% |
| Appearance | White to off-white solid. |
| Solubility | Soluble in water (50mg/ml). |
| InChi Key | PRRZDZJYSJLDBS-UHFFFAOYSA-N |
| Smiles | O=C(CBr)C(O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice |
Keep cool and dry. Protect from moisture and oxygen. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable pyruvic acid derivative.
- Hexokinase II (HK2) inhibitor.
- Useful agent for immunometabolism research.
- Antitumor agent. Inhibits the rate limiting step of glycolysis and effectively suppress tumor survival in vitro and in vivo. Displays potent cytotoxic activity against cancer cells with mitochondrial respiratory defects and cells in hypoxic environment.
- Antifungal agent (anticryptococcal).
- Also used as affinity label for cysteine residues and cross-linker between nucleic acids and proteins.
Product References
- Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate: Z. Chen, et al.; Biochim. Biophys. Acta 1787, 553 (2009)
- Specificity of the anti-glycolytic activity of 3-bromopyruvate confirmed by FDG uptake in a rat model of breast cancer: M. Buijs, et al.; Invest. New Drugs 27, 120 (2009)
- 3-Bromopyruvate: a novel antifungal agent against the human pathogen Cryptococcus neoformans: M. Dyląg, et al.; BBRC 434, 322 (2013)
- 3-Bromopyruvic acid, a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells : in vitro and in vivo findings: L. Gong, et al.; Anticancer Agents Med. Chem. 14, 771 (2014)
- A guide to immunometabolism for immunologists: L.A. O'Neill, et al.; Nat. Rev. Immunol. 16, 553 (2016)
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