Metformin . hydrochloride

Specifications / Handling

More Information
Product Details
Synonyms	1,1-Dimethylbiguanide . HCl; NSC 91485; DMGG; LA 6023
Product Type	Chemical
Properties
Formula	C₄H₁₁N₅ . HCl
MW	129.2 . 36.5
CAS	1115-70-4
RTECS	DU1800000
Purity Chemicals	≥98%
Appearance	White to off-white solid.
Solubility	Soluble in water (5mg/ml) or DMSO (5mg/ml).
Identity	Determined by ¹H-NMR.
InChi Key	OETHQSJEHLVLGH-UHFFFAOYSA-N
Smiles	CN(C(NC(N)=N)=N)C.Cl
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

AMPK activator.
Useful agent for immunometabolism research. Reported to stimulate AMP-activated protein kinase (AMPK), leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation. Mitochondrial electron transport chain complex I inhibitor, reducing mitochondrial reactive oxygen species (ROS).
Antidiabetic and anti-hyperglycemic agent that reduces blood glucose levels, improves insulin sensitivity and decreases insulin resistance. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway.
Used as weight-loss agent in obesity and as insulin sensitizer in nonalcoholic fatty liver disease (NAFLD). Leptin sensitizer to mediate the weight-loss effect in the brain.
Increases plasma concentrations of the glucose-lowering gut incretin hormone glucagon-like peptide-1 (GLP-1), which may contribute to metformin's glucose-lowering effect.
Anticancer agent with antiproliferative and proapoptotic activity in cancer cell lines.
Autophagy activator.
Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis.
Targets brown adipose tissue (BAT) in vivo and reduces oxygen consumption.
Anti-inflammatory agent. Described to suppress inflammatory responses by inhibition of nuclear factor κB (NF-κB) via AMPK-dependent and independent pathways. Also described to inhibit NLRP3 inflammasome activation, subsequent caspase-1 cleavage and interleukin-1β secretion.

Product References

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