AdipoGen Life Sciences

WZB117

CHF 480.00
In stock
AG-CR1-3694-M02525 mgCHF 480.00
AG-CR1-3694-M0055 mgCHF 480.00
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Product Details
Synonyms WZB-117; 3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate)
Product Type Chemical
Properties
Formula

C20H13FO6

MW 368.3
CAS 1223397-11-2
Purity Chemicals ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in DMSO (20mg/ml), ethanol (20mg/ml) or DMF (20mg/ml).
Identity Determined by 1H-NMR
InChi Key FRSWCCBXIHFKKY-UHFFFAOYSA-N
Smiles FC1=C(OC(C2=CC(O)=CC=C2)=O)C(OC(C3=CC=CC(O)=C3)=O)=CC=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Protect from moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Glucose transporter GLUT inhibitor (GLUT4 > GLUT1 = GLUT3). Fast-acting irreversible GLUT1 inhibitor. Binds directly to GLUT1 involving three hydrogen bonds, one each with Asn34, Arg126 and Trp412.
  • Blocks glucose transport in diverse cancer cells, reducing extracellular lactate and intracellular ATP levels and consequently decreases glycolysis.
  • Anticancer agent in vitro and in vivo. Inhibits cancer cell proliferation, resulting in cell cycle arrest, senescence and necrosis or apoptosis.
  • Inhibits the self-renewal and tumor-initiating capacity of cancer stem cells, blocking tumor initiation after implantation of cancer stem cells in mice.
Product References
  1. A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo: Y. Liu, et al.; Mol. Cancer Ther. 11, 1672 (2012)
  2. A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models: C. Xintaropoulou, et al.; Oncotarget 6, 25677 (2015)
  3. Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells: K. Shibuya, et al.; Oncotarget 6, 651 (2015)
  4. Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells: A. Koch, et al.; Oncotarget 6, 32748 (2015)
  5. WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) inhibits GLUT1-mediated sugar transport by binding reversibly at the exofacial sugar binding site: O.A. Ojelabi, et al. J. Biol. Chem. 291, 26762 (2016)
  6. Inhibition of Glut1 by WZB117 sensitizes radioresistant breast cancer cells to irradiation: F. Zhao, et al.; Cancer Chemother. Pharmacol. 77, 963 (2016)
  7. A guide to immunometabolism for immunologists: L.A. O'Neill, et al.; Nat. Rev. Immunol. 16, 553 (2016) (Review)
  8. Bioimaging of glucose analogs labeled at the C-1 or C-2 position with a fluorescent dansylamino group: M.Yanagida, et al.; Microscopy ahead of print (2023)
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