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AdipoGen Life Sciences
WZB117
480
CHF
CHF 480.00
In stock
AG-CR1-3694-M02525 mgCHF 480.00
AG-CR1-3694-M0055 mgCHF 480.00
| Product Details | |
|---|---|
| Synonyms | WZB-117; 3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate) |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H13FO6 |
| MW | 368.3 |
| CAS | 1223397-11-2 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO (20mg/ml), ethanol (20mg/ml) or DMF (20mg/ml). |
| Identity | Determined by 1H-NMR |
| InChi Key | FRSWCCBXIHFKKY-UHFFFAOYSA-N |
| Smiles | FC1=C(OC(C2=CC(O)=CC=C2)=O)C(OC(C3=CC=CC(O)=C3)=O)=CC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. Protect from moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Glucose transporter GLUT inhibitor (GLUT4 > GLUT1 = GLUT3). Fast-acting irreversible GLUT1 inhibitor. Binds directly to GLUT1 involving three hydrogen bonds, one each with Asn34, Arg126 and Trp412.
- Blocks glucose transport in diverse cancer cells, reducing extracellular lactate and intracellular ATP levels and consequently decreases glycolysis.
- Anticancer agent in vitro and in vivo. Inhibits cancer cell proliferation, resulting in cell cycle arrest, senescence and necrosis or apoptosis.
- Inhibits the self-renewal and tumor-initiating capacity of cancer stem cells, blocking tumor initiation after implantation of cancer stem cells in mice.
Product References
- A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo: Y. Liu, et al.; Mol. Cancer Ther. 11, 1672 (2012)
- A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models: C. Xintaropoulou, et al.; Oncotarget 6, 25677 (2015)
- Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells: K. Shibuya, et al.; Oncotarget 6, 651 (2015)
- Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells: A. Koch, et al.; Oncotarget 6, 32748 (2015)
- WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) inhibits GLUT1-mediated sugar transport by binding reversibly at the exofacial sugar binding site: O.A. Ojelabi, et al. J. Biol. Chem. 291, 26762 (2016)
- Inhibition of Glut1 by WZB117 sensitizes radioresistant breast cancer cells to irradiation: F. Zhao, et al.; Cancer Chemother. Pharmacol. 77, 963 (2016)
- A guide to immunometabolism for immunologists: L.A. O'Neill, et al.; Nat. Rev. Immunol. 16, 553 (2016) (Review)
- Bioimaging of glucose analogs labeled at the C-1 or C-2 position with a fluorescent dansylamino group: M.Yanagida, et al.; Microscopy ahead of print (2023)
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