MPLA (synthetic) Sterile Solution

CHF 320.00
In stock
AG-CU1-0002-C100100 µgCHF 320.00
More Information
Product Details
Synonyms Monophosphoryl Lipid A; Phosphorylated Hexaacyl Disaccharide; Glycopyranoside Lipid A; Glucopyranosyl Lipid Adjuvant; GLA
Product Type Chemical
Properties
Formula

C96H184N3O22P

MW 1763.47
CAS 1246298-63-4
Source/Host Chemicals Synthetic. Does not contain RNA, DNA or protein fragments.
Purity Chemicals No detectable TLR4 independent activity: standardised TLR4-specific agonist.
Appearance Colourless opaque aqueous solution.
Formulation Liquid.
Concentration 0.5mg/ml stabilized in sterile, double-distilled water (ddWater), without any additives.
Other Product Data

Preparation of Stock Solution: To yield a 50μg/ml (500-50x) stock solution add 100μl of MPLA to 900μl endotoxin-free and sterile ddWater (Cat. No.: IAX-900-002) (not PBS) and mix well.

InChi Key UPAZUDUZKTYFBG-UCUVALOBDI
Smiles [NH4+].CCCCCCCCCCCCCC(=O)O[C@H](CCCCCCCCCCC)CC(=O)N[C@@H]1[C@H](OCC2O[C@H](O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)C(OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H]2O)OC(CO)[C@@H](OP(O)([O-])=O)C1OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Do not freeze.
Ready-made solution is cell culture-grade. Prepare diluted MPLA working solutions in water just prior to use, keep sterile.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Toll-like receptor 4 (TLR4) activator. Activates TLR4 but does not activate TLR2 even at high concentrations.
  • Defined structure of MPLA.
  • Synthetic lipid A is structurally very similar to natural MPLA but does not exist in nature.
Product References
  1. Biological activities of synthetic lipid A analogs: pyrogenicity, lethal toxicity, anticomplement activity, and induction of gelation of Limulus amoebocytelysate: K. Tanamoto, et al.; Infect. Immun. 44, 42 (1984)
  2. Endotoxic properties of chemically synthesized lipid A part structures. Comparison of synthetic lipid A precursor and synthetic analogues with biosynthetic lipid A precursor and free lipid A: C. Galanos, et al.; Eur. J. Biochem. 140, 221 (1984)
  3. Role of innate immune factors in the adjuvant activity of monophosphoryl lipid A: M. Martin, et al.; Infect. Immun. 71, 2498 (2003)
  4. Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4 and myeloid differentiation factor 88-dependent signaling pathway: M. Martin, et al.; Int. Immunol. 14, 1325 (2003)
  5. Synthetic and natural TLR4 agonists as safe and effective vaccine adjuvants: C.B. Fox, et al.; Subcell. Biochem. 53, 303 (2010)
  6. A synthetic adjuvant to enhance and expand immune responses to influenza vaccines: R.N. Coler, et al.; PLoS One 5, e13677 (2010)
  7. CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS: T. Regen, et al.; Brain Behav. Immun. 25, 957 (2011)
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