AdipoGen Life Sciences
MPLA (synthetic) Sterile Solution
As low as
330
CHF
CHF 330.00
In stock
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AG-CU1-0002-C100100 µgCHF 330.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | Monophosphoryl Lipid A; Phosphorylated Hexaacyl Disaccharide; Glycopyranoside Lipid A; Glucopyranosyl Lipid Adjuvant; GLA |
| Product Type | Chemical |
| Properties | |
| Formula |
C96H184N3O22P |
| MW | 1763.47 |
| CAS | 1246298-63-4 |
| Source/Host Chemicals | Synthetic. Does not contain RNA, DNA or protein fragments. |
| Purity Chemicals | No detectable TLR4 independent activity: standardised TLR4-specific agonist. |
| Appearance | Colourless opaque aqueous solution. |
| Formulation | Liquid. |
| Concentration | 0.5mg/ml stabilized in sterile, double-distilled water (ddWater), without any additives. |
| Other Product Data |
Preparation of Stock Solution: To yield a 50μg/ml (500-50x) stock solution add 100μl of MPLA to 900μl endotoxin-free and sterile ddWater (Cat. No.: IAX-900-002) (not PBS) and mix well. |
| InChi Key | UPAZUDUZKTYFBG-UCUVALOBDI |
| Smiles | [NH4+].CCCCCCCCCCCCCC(=O)O[C@H](CCCCCCCCCCC)CC(=O)N[C@@H]1[C@H](OCC2O[C@H](O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)C(OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H]2O)OC(CO)[C@@H](OP(O)([O-])=O)C1OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice |
Do not freeze. Ready-made solution is cell culture-grade. Prepare diluted MPLA working solutions in water just prior to use, keep sterile. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Scientific Background Information
Product Description
- Toll-like receptor 4 (TLR4) activator. Activates TLR4 but does not activate TLR2 even at high concentrations.
- Defined structure of MPLA.
- Synthetic lipid A is structurally very similar to natural MPLA but does not exist in nature.
Product-specific References
- Biological activities of synthetic lipid A analogs: pyrogenicity, lethal toxicity, anticomplement activity, and induction of gelation of Limulus amoebocytelysate: K. Tanamoto, et al.; Infect. Immun. 44, 42 (1984)
- Endotoxic properties of chemically synthesized lipid A part structures. Comparison of synthetic lipid A precursor and synthetic analogues with biosynthetic lipid A precursor and free lipid A: C. Galanos, et al.; Eur. J. Biochem. 140, 221 (1984)
- Role of innate immune factors in the adjuvant activity of monophosphoryl lipid A: M. Martin, et al.; Infect. Immun. 71, 2498 (2003)
- Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4 and myeloid differentiation factor 88-dependent signaling pathway: M. Martin, et al.; Int. Immunol. 14, 1325 (2003)
- Synthetic and natural TLR4 agonists as safe and effective vaccine adjuvants: C.B. Fox, et al.; Subcell. Biochem. 53, 303 (2010)
- A synthetic adjuvant to enhance and expand immune responses to influenza vaccines: R.N. Coler, et al.; PLoS One 5, e13677 (2010)
- CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS: T. Regen, et al.; Brain Behav. Immun. 25, 957 (2011)