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AdipoGen Life Sciences
Leucettinib-92
130
CHF
CHF 130.00
In stock
AG-MR-C0049-M0011 mgCHF 130.00
AG-MR-C0049-M0055 mgCHF 430.00
AG-MR-C0049-M02525 mgCHF 1'290.00
NEW
| Product Details | |
|---|---|
| Synonyms | LCTB-92; (Z)-2-((Adamantan-1-yl)amino)-5-(benzo[d]thiazol-6-ylmethylene)-3,5-dihydro-4H-imidazol-4-one |
| Product Type | Chemical |
| Properties | |
| Formula |
C21H22N4OS |
| MW | 378.5 |
| CAS | 2732859-57-1 |
| Purity Chemicals | ≥99% (NMR) |
| Appearance | Pale yellow to off-white powder. |
| Solubility | Soluble in DMSO (10mM) or ethanol. |
| Reconstitution | Stock solutions can be made up to 10mM in DMSO. |
| Identity | Determined by 1H-NMR. |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
- Potent inhibitor of DYRK1A (IC50=1.2nM), DYRK1B (IC50=1.8nM), DYRK3 (IC50=19.3nM) and CLK2 (IC50=0.6nM) [1].
- Inhibits the phosphorylation of Tau at Thr212 and cyclin D1 at Thr286.
- Corrects cognitive deficits in animal models of Down syndrome.
- iso-Leucettinib-92 (Prod. No. AG-MR-C0050) is a kinase-inactive isomer and should be used as a negative control together with this compound.
Product References
- Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases: M.F. Lindberg, et al.; J. Med. Chem. 66, 4106 (2023)
- Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B: E. Deau, et al.; J. Med. Chem. 66, 10694 (2023)
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