CD40L [CD154] (human)-muCD8 Fusion Protein

CHF 460.00
In stock
ANC-505-02025 µgCHF 460.00
 
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Product Details
Product Type Protein
Properties
Source/Host CHO cells
Application Flow Cytometry
ELISA
Western Blot
Formulation 50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5% Gentamicin sulfate
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by Ancell Corporation.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 6 months after receipt when stored at +4°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Human CD154 (CD40 ligand) is a member of the TNF family and is expressed on the surface of activated T cells. It can undergo proteolytic cleavage into a 19kDa immunologically active soluble form. Interaction of CD154 and CD40 is essential for isotype switching in B cells. Known genetic defects that alter this interaction lead to impaired immune system function. Increased levels of CD154 has been associated with autoimmune disorders including SLE, CLL and eosinophilic fasciitis. CD154 has been reported to be expressed on vascular endothelial cells, smooth muscle cells, macrophages and activated platelets indicating a role for the CD40-CD154 immunoregulatory signaling in artherosclerosis and cardiovascular disorders.
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