CD244 [2B4] (human)-muIg Fusion Protein (preservative free)

Specifications / Handling

More Information
Product Details
Synonyms	2B4; SLAMF4
Product Type	Protein
Properties
Source/Host	CHO cells
Crossreactivity	Human
Application	ELISA Flow Cytometry
Label/Conjugates	Preservative Free
Specificity	Binds to recombinant CD48 in EIA and cell surface CD48 on Raji cell surface in FACS.
MW	~135kDa (native dimer)
Concentration	0.5mg/ml
Formulation	50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl
Protein Negative Control	MuIg Control Protein (preservative free)
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
Declaration	Manufactured by Ancell Corporation.
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 6 months after receipt when stored at +4°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

CD244 (2B4, SLAMF4) is a 66 kD member of the CD2/SLAM related receptor family (SRR). It is expressed on NK, T cell subsets, monocytes and eosinophils. It is expressed at high levels on Leuikemia initiating cells, and plays a role in their proliferative potential. In mice there are two transcription varients, a long form and a short form of CD244 each of which have distinct signaling properties. In humans, only the long form is expressed. Decreased CD244 expression on monocytes of SLE patients correlated (negatively) with autoantibody titers. CD244 mediated function in immune response can vary greatly dependant on the context of its ligation.

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