CD123 [IL-3Rα] (human)-muIg Fusion Protein (preservative free)

Specifications / Handling

More Information
Product Details
Synonyms	Interleukin-3 Receptor α
Product Type	Protein
Properties
Source/Host	CHO cells
Sequence	A soluble molecule consisting of the extracellular domain of mature human CD123 fused to murine IgG2a Fc.
Crossreactivity	Human
Application	ELISA
Label/Conjugates	Preservative Free
Purity Detail	Protein A and SEC purified.
Concentration	0.5mg/ml
Accession Number	P26951
Formulation	50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl
Protein Negative Control	MuIg Control Protein (preservative free)
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
Declaration	Manufactured by Ancell Corporation.
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 6 months after receipt when stored at +4°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Human CD123 (Interleukin-3 Receptor α) is a 70kDa type I transmembrane molecule, and is the low affinity receptor for the cytokine IL-3, which can stimulate proliferation or differentiation. When paired in a heterodimer with CD131 (IL-3Rβ), it binds IL-3 with much higher affinity. CD123 is found on myeloid precusors, stem cells, a subset of T cells, some B cells, megakaryocytes, basophils, monocytes and epithelial cells. CD123 is present at high levels on many hematologic malignancies, and antibodies and CAR T cells against CD123 have been used successfully to combat acute myeloid leukemia (AML).

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