Ancell

anti-CD4 (mouse), mAb (GK1.5) (preservative free)

CHF 260.00
In stock
ANC-704-820100 µgCHF 260.00
More Information
Product Details
Product Type Monoclonal Antibody
Properties
Clone GK1.5
Isotype Rat IgG2bκ
Immunogen/Antigen Mouse CTL-V4 membrane prep.
Label/Conjugates Preservative Free
Application

Flow Cytometry
Functional Application: T cell depletion (see Lit. 3)
ELISA
Immunohistochemistry:  (see Lit. 3)
Immunoprecipitation

Crossreactivity Mouse
Specificity

 Binds to an extracellular epitope of the 55kd CD4 molecule present on a murine T cell subset.

Purity ≥95% (SDS-PAGE)
Formulation 50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by Ancell Corporation.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

CD4 binds to MHC Class II expressed by antigen presenting cells, facilitating T cell receptor signaling.

Product References
  1. Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines: D.B. wilde, et al.; J. Immunol. 131, 2178 (1983)
  2. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule: D.P. Dialynas, et al.; J. Immunol. 131, 2445 (1983)
  3. Long-term intratracheal lipopolysaccharide exposure in mice results in chronic lung inflammation and persistent pathology: J.H. Vernooy, et al.; Am. J. Respir. Cell Mol. Biol. 26, 152 (2002)
  4. Suppression of Alkali Burn-Induced Corneal Neovascularization by Dendritic Cell Vaccination Targeting VEGF Receptor 2: H. Mochimaru, et al.; IOVS 49, 2172 (2008)
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