RIG-I (human) (rec.) (His) (active) (50µg)

Specifications / Handling

More Information
Product Details
Synonyms	Antiviral Innate Immune Response Receptor RIG-I; ATP-dependent RNA Helicase DDX58; DEAD Box Protein 58; RIG-I-like Receptor 1; RLR-1; Retinoic Acid-inducible Gene 1 Protein
Product Type	Protein
Properties
Source/Host	Insect cells
Sequence	Recombinant human RIG-I enzyme (aa1-925) fused to a C-terminal His-tag.
Crossreactivity	Human
Biological Activity	The enzyme has been thoroughly validated with the Transcreener ADP2 Assay Kit. For specific activity please refer to the Certificate of Analysis for each individual enzyme lot.
Purity	≥90% (SDS-PAGE)
Accession Number	O95786
Formulation	Liquid. In 20mM Tris, 500mM NaCl, 10% glycerol (pH 8.0).
Other Product Data	Click here for Complete Information from the Original Manufacturer Our product description may differ slightly from the original manufacturers product datasheet.
Shipping and Handling
Shipping	DRY ICE
Short Term Storage	-20°C
Long Term Storage	-80°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 6 months after receipt when stored at -80°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

RIG-I (retinoic acid-inducible gene I), is a cytosolic pattern recognition receptor (PRR) that induces type-I interferon (IFN1) in response to dsRNA. RIG-I is a critical sensor of RNA viral infections, recognizing double-stranded RNA, 4-triphosphylated RNAs, and other pathogen-associated molecular patterns (PAMPs) that indicate the presence of a virus. It then induces a Type I IFN response via the NFkB and IRF3 pathways.

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