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BellBrook
VPS4a (human) (rec.) (His) (active) (200µg)
As low as
1797
CHF
CHF 1’797.00
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Only %1 left
BBL-2346-C200200 µgCHF 1’797.00
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| Product Details | |
|---|---|
| Synonyms | Vacuolar Protein Sorting-associated Protein 4A; Protein SKD2 |
| Product Type | Protein |
| Properties | |
| Source/Host | Insect cells |
| Sequence |
Human VPS4A (aa 111-437)with an N-terminal His-tag. |
| Crossreactivity | Human |
| Application |
Drug Discovery |
| Biological Activity |
The enzyme has been thoroughly validated with the Transcreener ADP2 Assay Kit. |
| MW | ~37.2kDa |
| Purity | ≥85% (SDS-PAGE) |
| Accession Number | Q9UN37 |
| Formulation | Liquid. In 20mM HEPES, 500mM NaCl, 1mM TCEP, and 10% Glycerol (pH 7.6). |
| Other Product Data |
Click here for Complete Information from the Original Manufacturer Human VPS4A: Q9UN37 |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -80°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -80°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
VPS4A is an ATPase associated with diverse cellular activities. It plays a key role in the endosomal sorting complex required for transport (ESCRT) pathway, which is crucial for endosomal trafficking, multivesicular body (MVB) formation, cCytokinesis (cell division) and viral budding (many enveloped viruses hijack VPS4A to exit cells). It helps disassemble ESCRT-III complexes in an ATP-dependent manner, recycling components for repeated use. VPS4A dysfunction can disrupt cell division and vesicle trafficking in addition, viruses such as HIV, Ebola, and others require VPS4A activity for efficient budding.
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