BLM Helicase (human) (rec.) (His) (active) (50µg)

The Bloom Syndrome Helicase (BLM) protein is a member of the RecQ family of DNA helicases that plays a central role in maintaining genome stability. BLM functions as a 3′→5′ DNA helicase with the ability to unwind a wide variety of DNA structures, including replication forks, G-quadruplexes, and Holliday junctions. Through these activities, BLM participates in critical DNA metabolic processes such as replication, homologous recombination, and DNA double-strand break repair. A hallmark function of BLM is its role in dissolving recombination intermediates to prevent excessive crossover events, thereby suppressing sister chromatid exchanges. Loss of BLM function results in genomic instability, elevated sister chromatid exchange rates, growth abnormalities, immunodeficiency, and a marked predisposition to cancer. As a guardian of genome integrity, BLM helicase remains a key focus in studies of DNA repair mechanisms and cancer biology.