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BellBrook
Enzolution™ RIG-I ATPase TR-FRET Assay System
CHF 0.00
In stock
BBL-3035-TR-1K1000 assaysCHF 927.00
BBL-3035-TR-10K10000 assaysCHF 4'673.00
BBL-3035-TR-100K10 x 10000 assaysINQ
Figure 1: Schematic Overview of the RIG-I ATPase Assay System with the Transcreener® ADP2 Assays.
| Product Details | |
|---|---|
| Synonyms | Antiviral Innate Immune Response Receptor RIG-I; ATP-dependent RNA Helicase DDX58; DEAD Box Protein 58; RIG-I-like Receptor 1; RLR-1; Retinoic Acid-inducible Gene 1 Protein |
| Product Type | Kit |
| Properties | |
| Application Set | Compound Screening |
| Crossreactivity | Human |
| Quantity |
1000 assays/384wells (BBL-3035-TR-1K) 10000 assays/384wells (BBL-3035-TR-10K) 100000 assays/384wells (BBL-3035-TR-100K) Note: The exact number of assays depends on enzyme reaction conditions. |
| Detection Type | TR-FRET |
| Kit Contains |
- RIG-I enzyme (human) (rec.) (His) |
| Other Product Data |
Click here for Complete Information from the Original Manufacturer |
| Declaration | Manufactured by BellBrook Labs. |
| Accession Number | O95786 |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Documents | |
| Manual |
 Download PDF |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
RIG-I is a critical sensor of RNA viral infections, recognizing double-stranded RNA, 4-triphosphylated RNAs, and other pathogen-associated molecular patterns (PAMPs) that indicate the presence of a virus. It then induces a Type I IFN response via the NFkB and IRF3 pathways. The RIG-I Assay System is a valuable tool to advance drug discovery efforts in innate immune system pathways and to screen and profile RIG-I inhibitors.
The RIG-I ATPase Assay System includes RIG-I (Retinoic acid-inducible gene I) enzyme, substrate, assay plates, and buffers required for a RIG-I enzymatic reaction. The Transcreener ADP2 Assay (sold separately), a far-red competitive assay designed for HTS and inhibitor dose-response measurements, measures ADP produced to determine activity.
When purchasing the RIG-I assay system, it is important to choose the assay system readout corresponding to the TR-FRET configuration of your Transcreener ADP2 Assay Kit!
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