Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
BellBrook
Enzolution™ RIG-I ATPase TR-FRET Assay System
CHF 0.00
In stock
BBL-3035-TR-1K1000 assaysCHF 927.00
BBL-3035-TR-10K10000 assaysCHF 4'673.00
BBL-3035-TR-100K10 x 10000 assaysINQ
NEW
Figure 1: Schematic Overview of the RIG-I ATPase Assay System with the Transcreener® ADP2 Assays.
| Product Details | |
|---|---|
| Synonyms | Antiviral Innate Immune Response Receptor RIG-I; ATP-dependent RNA Helicase DDX58; DEAD Box Protein 58; RIG-I-like Receptor 1; RLR-1; Retinoic Acid-inducible Gene 1 Protein |
| Product Type | Kit |
| Properties | |
| Application Set | Compound Screening |
| Crossreactivity | Human |
| Quantity |
1000 assays/384wells (BBL-3035-TR-1K) 10000 assays/384wells (BBL-3035-TR-10K) 100000 assays/384wells (BBL-3035-TR-100K) Note: The exact number of assays depends on enzyme reaction conditions. |
| Detection Type | TR-FRET |
| Kit Contains |
- RIG-I enzyme (human) (rec.) (His) |
| Other Product Data |
Click here for Complete Information from the Original Manufacturer |
| Declaration | Manufactured by BellBrook Labs. |
| Accession Number | O95786 |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Documents | |
| Manual |
 Download PDF |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
RIG-I is a critical sensor of RNA viral infections, recognizing double-stranded RNA, 4-triphosphylated RNAs, and other pathogen-associated molecular patterns (PAMPs) that indicate the presence of a virus. It then induces a Type I IFN response via the NFkB and IRF3 pathways. The RIG-I Assay System is a valuable tool to advance drug discovery efforts in innate immune system pathways and to screen and profile RIG-I inhibitors.
The RIG-I ATPase Assay System includes RIG-I (Retinoic acid-inducible gene I) enzyme, substrate, assay plates, and buffers required for a RIG-I enzymatic reaction. The Transcreener ADP2 Assay (sold separately), a far-red competitive assay designed for HTS and inhibitor dose-response measurements, measures ADP produced to determine activity.
When purchasing the RIG-I assay system, it is important to choose the assay system readout corresponding to the TR-FRET configuration of your Transcreener ADP2 Assay Kit!
Related Products
