BellBrook

Enzolution™ RIG-I ATPase TR-FRET Assay System

CHF 0.00
In stock
BBL-3035-TR-1K1000 assaysCHF 927.00
BBL-3035-TR-10K10000 assaysCHF 4'673.00
BBL-3035-TR-100K10 x 10000 assaysINQ
NEW
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Product Details
Synonyms Antiviral Innate Immune Response Receptor RIG-I; ATP-dependent RNA Helicase DDX58; DEAD Box Protein 58; RIG-I-like Receptor 1; RLR-1; Retinoic Acid-inducible Gene 1 Protein
Product Type Kit
Properties
Application Set Compound Screening
Crossreactivity Human
Quantity

1000 assays/384wells (BBL-3035-TR-1K)

10000 assays/384wells (BBL-3035-TR-10K)

100000 assays/384wells (BBL-3035-TR-100K)

Note: The exact number of assays depends on enzyme reaction conditions.

Detection Type TR-FRET
Kit Contains

- RIG-I enzyme (human) (rec.) (His)
- RIG-I dsDNA
- Enzyme Assay Buffer C, 10X
- 1M DTT
- 384-Well Low Volume Assay Plates (Corning#4513; sold under #BBL-2231 or BBL-2232)

Other Product Data

Click here for Complete Information from the Original Manufacturer
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by BellBrook Labs.
Accession Number O95786
Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Documents
Manual Download PDF
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

RIG-I is a critical sensor of RNA viral infections, recognizing double-stranded RNA, 4-triphosphylated RNAs, and other pathogen-associated molecular patterns (PAMPs) that indicate the presence of a virus. It then induces a Type I IFN response via the NFkB and IRF3 pathways. The RIG-I Assay System is a valuable tool to advance drug discovery efforts in innate immune system pathways and to screen and profile RIG-I inhibitors. 

The RIG-I ATPase Assay System includes RIG-I (Retinoic acid-inducible gene I) enzyme, substrate, assay plates, and buffers required for a RIG-I enzymatic reaction. The Transcreener ADP2 Assay (sold separately), a far-red competitive assay designed for HTS and inhibitor dose-response measurements, measures ADP produced to determine activity.

When purchasing the RIG-I assay system, it is important to choose the assay system readout corresponding to the TR-FRET configuration of your Transcreener ADP2 Assay Kit!

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