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Bertin Bioreagent
anti-Prion Protein, mAb (2G11)
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CHF 579.00
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BRT-A03225-C200200 µgCHF 579.00
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| Product Details | |
|---|---|
| Synonyms | PrP |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 2G11 |
| Isotype | Mouse IgG2a |
| Source/Host | Mouse |
| Immunogen/Antigen | This anti-Prion Protein Monoclonal Antibody was raised against a synthetic peptide (146-182) of the ovine PrP peptide. |
| Application | Immunohistochemistry for sheep PrPres without PK treatment. For immunohistochemistry, the optimal working dilution must be determined empirically (currently between 0.1 and 1 µg/mL). Mab 2G11 binds to the partially denatured or oxidized normal prion protein in vitro and as such is an indicator (by lack of signal) of preservation of the native state. |
| Specificity | PrPres, (+) Caprine, (+) Ovine, (+/-) Bovine, (+/-) Mouse, (+) Bovine Linked with 12F10, (-) Human, (-) Hamster. |
| Formulation | Lyophilized. With BSA. |
| Reconstitution | Reconstitute the content of the vial in 1 mL of water. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Prion Protein (PrP) and namely its abnormal isoform, partially resistant to proteinase K (PrPres), is the only specific molecular marker of the Transmissible Spongiform Encephalopathies (TSEs) such as Bovine Spongiform Encephalopathie (BSE) or its human form, the New Variant of Creutzfeld-Jakob disease. This antibody recognises the 149-161 peptide motif on the ovine sequence that is EDRYYRENMYRYP.