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Bertin Bioreagent
anti-CGRP (human,rat), mAb (83)
As low as
812
CHF
CHF 812.00
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BRT-A03481-C200200 µgCHF 812.00
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| Product Details | |
|---|---|
| Synonyms | Calcitonin Gene-related Peptide |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | CGRP83 |
| Source/Host | Mouse |
| Immunogen/Antigen | Rat CGRPalpha-KLH |
| Application | EIA |
| Formulation | Lyophilized or Liquid. Phosphate Buffer. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. It exists in two major forms that share greater than 90% sequence homology, α-CGRP that is produced by alternative RNA splicing of the calcitonin gene CALCI and β-CGRP that is encoded by CALCII in humans. CGRP is primarily expressed in A and Cδ fibers and exhibits perivascular localization but is also expressed in keratinocytes and endothelial progenitor cells. CGRP binds to a heteromeric complex of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) and has roles in efferent function, nociception, and vasodilation. Levels of CGRP are increased in various pain states, including migraine.