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Bertin Bioreagent
anti-COX1, mAb
As low as
715
CHF
CHF 715.00
In stock
Only %1 left
BRT-A03583-C200200 µgCHF 715.00
| Product Details | |
|---|---|
| Synonyms | Cyclooxygenase-1; Prostaglandin Endoperoxide Synthase 1; Prostaglandin G/H Synthase 1; Prostaglandin H2 Synthase 1; PGHS-1 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Source/Host | Mouse |
| Immunogen/Antigen | Purified ovine COX. |
| Application | EIA |
| Formulation | Liquid. In Phosphate Buffer. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Cyclooxygenase 1 (COX-1) is a bifunctional enzyme that exhibits both COX and peroxidase activities. COX-1 is constitutively expressed in the gastrointestinal tract, kidney, spleen, liver, and lung and localizes to the endoplasmic reticulum. The COX component converts arachidonic acid to a hydroperoxyl endoperoxide prostaglandin G2 (PGG2) and the peroxidase component reduces the endoperoxide to the corresponding alcohol PGH2, the precursor of PGs, thromboxanes, and prostacyclins. COX-1 is the target of many non-steroidal anti-inflammatory drugs (NSAIDs) and is responsible for the undesirable gastrointestinal and renal side effects, such as ulcer formation and reductions in the glomerular filtration rate, respectively.