IL-17A (pig) ELISA Kit

Interleukin-17A (IL-17A) is one of the six members of the IL-17 family (from IL-17A to IL-17F). IL-17A is a polypeptide of 132 amino acids with a molecular weight of 14.9 kDa. IL-17A structure contains 4 antiparallel strands connected by two disulfides bridges. It can form either a homodimer or a heterodimer with IL-17F. Cells from the lymphoid lineage (CD4+ T cells, Th17 subpopulation, NK cells) and Paneth cells have been identified as producers of IL-17A. IL-17A is a proinflammatory mediator, its upregulation is find in many diseases like skin disorders (psoriasis, acne inversa) or Crohn's disease. Enzyme ImmunoAssay (EIA) is a technique to detect and quantify antigens (proteins, hormones�) or antibodies in samples. It relies on the ability of an antibody to bind a specific antigen. Either the antibody or the antigen is labelled with an enzyme whose substrate is a chromogen or a fluorogen converted in a measurable product (color or fluorescence). Enzyme-linked Immunosorbent Assay (ELISA) is a type of EIA using a solid phase (ex: microtiter plate) coated with an antigen immobilizing the molecule to detect. Over the time, scientists have extended the term ELISA to EIAs using an antibody coating the solid phase. That explains why our EIA kits using coated antibodies are also called ELISA kits.