IL-22 (pig) ELISA Kit

Interleukin 22 (IL-22) is one of the 9 members of the IL-10 family (IL-10/IL-19/IL-20/IL-22/IL-24/IL-26/IL-28A/IL-28B and IL-29). IL-22 is a polypeptide of 146 amino acids with a molecular weight of 16.7 kDa. IL-22 structure contains six antiparallel helices. It is produced at a monomeric state by cells from the lymphoid lineage (CD4+ T cells, Th22 subpopulation, NK cells) . This cytokine acts only on non-hematopoietic stromal cells, in particular epithelial cells, keratinocytes, and hepatocytes. IL-22 increases the innate immunity of tissue cells (induction of antimicrobial molecules), protects tissues from damage, and enhances their regenerations. Upregulation is find in many diseases like psoriasis and Crohn's disease. Enzyme ImmunoAssay (EIA) is a technique to detect and quantify antigens (proteins, hormones�) or antibodies in samples. It relies on the ability of an antibody to bind a specific antigen. Either the antibody or the antigen is labelled with an enzyme whose substrate is a chromogen or a fluorogen converted in a measurable product (color or fluorescence). Enzyme-linked Immunosorbent Assay (ELISA) is a type of EIA using a solid phase (ex: microtiter plate) coated with an antigen immobilizing the molecule to detect. Over the time, scientists have extended the term ELISA to EIAs using an antibody coating the solid phase. That explains why our EIA kits using coated antibodies are also called ELISA kits.