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Bertin Bioreagent
anti-NCoR, mAb (1D10)
As low as
777
CHF
CHF 777.00
In stock
Only %1 left
BRT-G01021-R100100 µlCHF 777.00
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| Product Details | |
|---|---|
| Synonyms | Nuclear Receptor Corepressor 1; N-CoR1 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 1D10 |
| Isotype | Mouse IgG1κ |
| Source/Host | Mouse |
| Immunogen/Antigen | Recombinant human N-CoR protein. |
| Application | ELISA, Western Blot, Immunofluorescence. Recommended dilution: 1/500-1/5000 |
| Specificity | Recognizes human N-CoR protein. Epitope between aa 1629 and 2440. |
| Formulation | Liquid. Does not contain any preservative. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
NCOR (Nuclear Receptor Corepressor 1) is a corepressor protein that inhibits gene transcription by interacting with nuclear receptors and other transcription factors. It plays a crucial role in regulating gene expression, metabolism, and cell differentiation by repressing target genes when transcription is not needed. NCOR binds to nuclear receptors (NRs) or transcription factors when there is no ligand (hormone) present. It recruits histone deacetylases (HDACs) to tighten chromatin. When a ligand (hormone like thyroid hormone or retinoic acid) binds to the receptor, NCOR is released. NCOR interacts with many transcription factors and nuclear receptors, including Thyroid Hormone Receptor (TR), Retinoic Acid Receptor (RAR), Peroxisome Proliferator-Activated Receptor (PPAR), Glucocorticoid Receptor (GR), Androgen Receptor (AR) & Estrogen Receptor (ER).