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Bertin Bioreagent
anti-RXRβ (Retinoid X receptor β), mAb (2E1)
As low as
CHF 778.00
In stock
Only %1 left
BRT-G01036-R100100 µlCHF 778.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | Retinoid X Receptor beta; Nuclear Receptor Subfamily 2 Group B Member 2; RXRB; NR2B2 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 2E1 |
| Isotype | Mouse IgG1κ |
| Source/Host | Mouse |
| Immunogen/Antigen | Synthetic peptide. |
| Application | ELISA, Western Blot (transfected cells), Immunocytochemistry (transfected cells), Gel shift (transfected cells). Recommended dilutions: 1/500-1/5000 |
| Specificity | Recognizes mouse and human RXR beta. No cross-reactivity on RXR alpha and RXR gamma. |
| Formulation | Liquid. Does not contain any preservative. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
Retinoid X Receptor Alpha (RXRβ) is a type of nuclear receptor that functions as a transcription factor. It plays a crucial role in regulating gene expression in response to ligands such as retinoids (derivatives of vitamin A) and other signaling molecules. Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. RXRβ forms homodimers (RXR-RXR) or heterodimers with other nuclear receptors like retinoic acid receptor (RAR), peroxisome proliferator-activated receptors (PPARs), liver X receptor (LXR), farnesoid X receptor (FXR) or vitamin D receptor (VDR). These dimeric complexes regulate genes involved in cell differentiation and proliferation, lipid metabolism, immune system modulation, and neuronal development. RXRβ dysregulation has been linked to various diseases, including cancer, metabolic disorders (e.g., obesity, diabetes), autoimmune disorders or neurodegenerative disorders.