anti-RXRγ (Retinoid X receptor γ), mAb (2D3)

Retinoid X Receptor Alpha (RXRγ) is a type of nuclear receptor that functions as a transcription factor. It plays a crucial role in regulating gene expression in response to ligands such as retinoids (derivatives of vitamin A) and other signaling molecules. Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. RXRγ forms homodimers (RXR-RXR) or heterodimers with other nuclear receptors like retinoic acid receptor (RAR), peroxisome proliferator-activated receptors (PPARs), liver X receptor (LXR) or vitamin D receptor (VDR). These dimeric complexes regulate genes involved in neurodevelopment and brain function, skeletal muscle differentiation, lipid metabolism, glucose homeostasis, and bone formation. RXRγ dysregulation has been linked to various diseases, including cancer, metabolic disorders (e.g., obesity, diabetes), muscle and bone disorders or neurological disorders.