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Bertin Bioreagent
anti-SMRT, mAb (10E6)
As low as
664
CHF
CHF 664.00
In stock
Only %1 left
BRT-G01038-R100100 µlCHF 664.00
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| Product Details | |
|---|---|
| Synonyms | Silencing Mediator for Retinoid and Thyroid Receptors; NCOR2; Nuclear Receptor Corepressor 2; SMAP 270; TRAC; CTG Repeat Protein 26 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 1E7 |
| Isotype | Mouse IgG2aκ |
| Source/Host | Mouse |
| Immunogen/Antigen | Recombinant human SMRT protein. |
| Application | ELISA, Western Blot, Immunofluorescence. Recommended dilutions: 1/500-1/5000 |
| Specificity | Recognizes human SMRT protein. Epitope between aa 982 and 1695. |
| Formulation | Liquid. Does not contain any preservative. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
SMRT is a corepressor protein that regulates gene transcription by repressing nuclear receptor activity. It recruits histone deacetylases (HDACs) to condense chromatin, making genes less accessible for transcription. SMRT interacts with ligand-dependent and ligand-independent transcription factors, including retinoic acid receptors (RARs), thyroid hormone receptors (TRs), peroxisome proliferator-activated receptors (PPARs), liver X receptor (LXR) or estrogen-related receptors (ERRs). SMRT plays a role in various biological processes, and its dysfunction is associated with cancer, metabolic disorders or neurological disorders.