anti-TRRAP, mAb (2D5)

Specifications / Handling

More Information
Product Details
Synonyms	Transformation/Transcription Domain-Associated Protein; 350/400 kDa PCAF-associated Factor (PAF350/400); STAF40; Tra1 Homolog
Product Type	Monoclonal Antibody
Properties
Clone	2D5
Isotype	Mouse IgG1κ
Source/Host	Mouse
Immunogen/Antigen	Synthetic peptide coupled to ovalbumin.
Application	ELISA, Western Blot (natural and recombinant proteins), Immunofluorescence, Immunoprecipitation, Chromatin IP. Recommended dilutions: 1/500 - 1/5000
Specificity	Recognizes human and mouse TRRAP.
Formulation	Liquid. Does not contain any preservative.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
Declaration	Manufactured by Bertin Bioreagent
Shipping and Handling
Shipping	BLUE ICE
Long Term Storage	-20°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 3 years after receipt when stored at -20°C.
Documents
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

TRRAP is an adaptor protein/cofactor involved in chromatin remodeling and transcriptional regulation. It plays a crucial role in histone acetylation, cell cycle control, and oncogenesis. TRRAP is a scaffold protein that recruits histone acetyltransferases (HATs) like Tip60, GCN5, and PCAF, leading to chromatin relaxation and gene activation. TRRAP is required for the oncogenic activity of MYC, a key regulator of cell proliferation. It also interacts with p53, a tumor suppressor, linking it to DNA damage response. TRRAP is essential for cell cycle progression and is involved in the DNA damage repair process. TRRAP is upregulated in multiple cancers promoting tumor growth and survival.

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