anti-GCN5, mAb (2C11)

GCN5 is a histone acetyltransferase (HAT) that plays a key role in epigenetic regulation, particularly in gene transcription by modifying chromatin structure. GCN5 functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It acts as a coactivator for various transcription factors and is involved in regulating genes related to cell growth, differentiation, and stress responses. Acetylation of histones gives a specific tag for epigenetic transcription activation. It has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. It regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. GCN5 is a component of the Ada Two-A containing (ATAC) complex, a complex with histone acetyltransferase activity on histones H3 and H4.