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Bertin Bioreagent
anti-Heterochromatin Protein 1α (HP-1 α), mAb (1H5)
As low as
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CHF 887.00
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BRT-G01047-R100100 µlCHF 887.00
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| Product Details | |
|---|---|
| Synonyms | HP1alpha; Chromobox Protein Homolog 5; CBX5; Antigen p25 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 1H5 |
| Isotype | Mouse IgG1κ |
| Source/Host | Mouse |
| Immunogen/Antigen | Recombinant mouse HP1alpha. |
| Application | ELISA, Immunohistochemistry, Immunofluorescence, Immunoprecipitation, ChIP. Recommended dilution: 1/500 - 1/5000. For western blot we recommend the clone 2HP-2G9. |
| Specificity | Recognizes human and mouse HP-1 alpha. Epitope between aa 67 and 119. |
| Formulation | Liquid. Does not contain any preservative. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Heterochromatin Protein 1 α is a chromatin-associated protein that plays a crucial role in maintaining heterochromatin structure, gene regulation, and genome stability. HP1α binds to methylated histone H3 (H3K9me3), a hallmark of heterochromatin, promoting gene silencing. HP1α participates in the DNA damage response by facilitating repair mechanisms at damaged sites. It is essential for proper chromosome condensation and segregation during cell division. HP1α interacts with DNA methyltransferases and histone modifiers to maintain epigenetic memory. HP1&akpha; levels are dysregulated in various cancers, affecting tumor growth and metastasis and abnormal HP1α function is linked to neurodevelopmental and neurodegenerative diseases.