anti-Heterochromatin Protein 1γ (HP-1γ), mAb (1G6)

Heterochromatin Protein 1 γ is a chromatin-binding protein. Unlike HP1α and HP1β, which are primarily associated with heterochromatin and gene silencing, HP1γ has a more dynamic role in both heterochromatin and euchromatin, influencing gene regulation, genome stability, and transcriptional activation. HP1γ binds to H3K9me3 but is also found in euchromatin, where it can promote transcription instead of repressing it. HP1γ interacts with RNA polymerase II and participates in the DNA damage response, particularly in homologous recombination (HR) repair. HP1γ is often upregulated in cancers, including breast and colorectal cancer, where it contributes to cell proliferation and metastasis. Alterations in HP1γ levels have been linked to neurodevelopmental and neurodegenerative diseases.