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Bertin Bioreagent
anti-Histone H4 acetylated (K12), mAb (4C10)
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CHF 664.00
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BRT-G01059-R100100 µlCHF 664.00
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| Product Details | |
|---|---|
| Synonyms | H4 K12ac |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 4C10 |
| Isotype | Mouse IgG1κ |
| Source/Host | Mouse |
| Immunogen/Antigen | Synthetic peptide: MSGRG(acetyl-K)GG(acetyl-K)GLG(acetyl-K)GGA(acetyl-K)RHRKVLR-(C) corresponding to aa 1 to 24 of human Histone H4. This sequence is conserved in a wide range of species. |
| Application | ELISA, Western Blot, Immunoprecipitation. Recommended dilutions: 1/500-1/5000. |
| Specificity | Recognizes acetylated (K12) Histone H4. |
| Formulation | Liquid. Does not contain any preservative. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Histone H4 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H4 is involved with the structure of the nucleosome of the 'beads on a string' organization. Histone proteins are highly post-translationally modified. Covalently bonded modifications include acetylation and methylation of the N-terminal tails. These modifications may alter expression of genes located on DNA associated with its parent histone octamer. Histone H4 is an important protein in the structure and function of chromatin, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes.