Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
Bertin Bioreagent
anti-AID (Activation induced cytidine deaminase), mAb (2E11)
As low as
777
CHF
CHF 777.00
In stock
Only %1 left
BRT-G01066-R100100 µlCHF 777.00
NEW
| Product Details | |
|---|---|
| Synonyms | Activation-Induced Cytidine Deaminase; Single-stranded DNA Cytosine Deaminase; Cytidine Aminohydrolase; EC:3.5.4.38 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 2E11 |
| Isotype | Mouse IgG1κ |
| Source/Host | Mouse |
| Immunogen/Antigen | Synthetic peptide coupled to ovalbumin. |
| Application | ELISA, Western Blot, Immunofluorescence, Immunoprecipitation. Recommended dilutions: 1/500 - 1/5000. |
| Specificity | Recognizes mouse and human AID. |
| Formulation | Liquid. Does not contain any preservative. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
AID is a 24 kDa RNA-editing enzyme that converts cytosine into uracil. It plays a critical role during B cell development, specifically in somatic hypermutation (SHM) and immunoglobulin class switch recombination (CSR). Changes in levels of AID expression typically present with disease. For example, mutations in AID are found in Hyper-IgM Syndrome (type 2), a disease form without opportunistic infections, while overexpression correlates with poor prognosis in chronic lymphocytic leukemia/small lymphocytic lymphoma. AID is functionally linked to histone deacetylases (HDACs) in the regulation of gene expression and antibody diversification. AID is essential for class switch recombination (CSR) in B cells.