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Bertin Bioreagent
anti-XPA (Xeroderma pigmentosum group A protein), mAb (1E11)
As low as
CHF 778.00
In stock
Only %1 left
BRT-G01068-R100100 µlCHF 778.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | Xeroderma Pigmentosum Group A-complementing Protein; DNA Repair Protein Complementing XP-A Cells |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 1E11 |
| Isotype | Mouse IgG1κ |
| Source/Host | Mouse |
| Immunogen/Antigen | Synthetic peptide. |
| Application | ELISA, Western Blot, Immunoprecipitation, Immunocytochemistry. Recommended dilutions: 1/500-1/5000. |
| Specificity | Recognizes human XPA. |
| Formulation | Liquid. Does not contain any preservative. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
XPA is a DNA repair protein that plays a crucial role in the nucleotide excision repair (NER) pathway, which removes bulky DNA lesions, such as those caused by UV radiation, chemical damage, and carcinogens. XPA binds to damaged DNA and helps verify the presence of DNA lesions. It works with other proteins like RPA (Replication Protein A) to ensure the damage is correctly identified before repair. Mutations in the XPA gene cause Xeroderma Pigmentosum (XP-A subtype). This leads to extreme UV sensitivity, high skin cancer risk, and neurological abnormalities in severe cases.