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Bertin Bioreagent
anti-XPB (Xeroderma pigmentosum group B), mAb (1B3)
As low as
777
CHF
CHF 777.00
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BRT-G01069-R100100 µlCHF 777.00
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| Product Details | |
|---|---|
| Synonyms | Xeroderma Pigmentosum Group B-complementing Protein; DNA Repair Protein Complementing XP-B Cells; General Transcription and DNA Repair Factor IIH Helicase/Translocase Subunit XPB; TFIIH subunit XPB; DNA Excision Repair Protein ERCC-3 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 1B3 |
| Isotype | Mouse IgG1κ |
| Source/Host | Mouse |
| Immunogen/Antigen | Recombinant human TFIIHp89/XPB protein. |
| Application | ELISA, Western Blot, Immunoprecipitation, Immunocytochemistry, Immunohistochemistry, ChIP. Recommended dilutions: 1/500-1/5000. |
| Specificity | Recognizes human TFIIHp89/XPB. |
| Formulation | Liquid. Does not contain any preservative. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
XPB is a DNA helicase and a key component of the Nucleotide Excision Repair (NER) pathway and transcription initiation and functions primarily in DNA unwinding to facilitate repair and transcription. XPB is part of the TFIIH complex, which is essential for nucleotide excision repair (NER). It unwinds DNA around damaged sites, allowing repair factors to access and excise the damaged region. Mutations in XPB (ERCC3) lead to Xeroderma Pigmentosum (XP-B subtype). This leads to extreme UV sensitivity, high risk of skin cancer, and sometimes neurological defects.