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Bertin Bioreagent
anti-XPC (Xeroderma pigmentosum group C), mAb (2H1)
As low as
CHF 778.00
In stock
Only %1 left
BRT-G01071-R100100 µlCHF 778.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | Xeroderma Pigmentosum Group C-complementing Protein; DNA Repair Protein Complementing XP-C Cells |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 2H1 |
| Isotype | Mouse IgG1κ |
| Source/Host | Mouse |
| Immunogen/Antigen | Synthetic peptide. |
| Application | ELISA, Western Blot, Immunocytochemistry. Recommended dilutions: 1/500-1/5000. |
| Specificity | Recognizes human XPC. |
| Formulation | Liquid. Does not contain any preservative. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
XPC is a DNA damage recognition protein that plays a critical role in the Nucleotide Excision Repair (NER) pathway. It is essential for detecting helix-distorting DNA lesions, such as those caused by UV radiation, carcinogens, and oxidative stress. It recognizes distorted DNA structures (e.g., UV-induced cyclobutane pyrimidine dimers, bulky adducts). Mutations in XPC lead to Xeroderma Pigmentosum (XP-C subtype). This leads to extreme UV sensitivity, freckling, pigmentation issues, and premature aging.