Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
Bertin Bioreagent
anti-XPD (Xeroderma pigmentosum group D), mAb (2F6)
As low as
CHF 778.00
In stock
Only %1 left
BRT-G01072-R100100 µlCHF 778.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | Xeroderma Pigmentosum Group D-complementing Protein; DNA Repair Protein Complementing XP-D Cells; General Transcription and DNA Repair Factor IIH Helicase/Translocase Subunit XPD; TFIIH subunit XPD; DNA Excision Repair Protein ERCC-2 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 2F6 |
| Isotype | Mouse IgG1κ |
| Source/Host | Mouse |
| Immunogen/Antigen | Synthetic peptide. |
| Application | ELISA, Western Blot, Immunoprecipitation, Immunocytochemistry. Recommended dilutions: 1/500-1/5000. |
| Specificity | Recognizes human and mouse TFIIHp80/XPD. |
| Formulation | Liquid. Does not contain any preservative. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
XPD is a DNA helicase that plays a critical role in both Nucleotide Excision Repair (NER) and transcription. It is part of the TFIIH complex, where it functions alongside XPB to unwind DNA during repair and transcription initiation. XPD works as a 5? to 3? helicase, separating the DNA strands around a lesion. It functions after damage recognition (by XPC) and verification (by XPA). XPD interacts with checkpoint proteins that regulate cell cycle progression after DNA damage. It may also influence apoptosis in response to severe damage. Mutations in XPD (ERCC2) cause Xeroderma Pigmentosum (XP-D). This leads to extreme UV sensitivity, freckling, and pigmentation abnormalities.