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Bertin Bioreagent
anti-XPG (Xeroderma pigmentosum group G), mAb (1B5)
As low as
CHF 778.00
In stock
Only %1 left
BRT-G01073-R100100 µlCHF 778.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | Xeroderma Pigmentosum Group G-complementing Protein; DNA Repair Protein Complementing XP-G Cells; DNA Excision Repair Protein ERCC-5 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 1B5 |
| Isotype | Mouse IgG1κ |
| Source/Host | Mouse |
| Immunogen/Antigen | Synthetic peptide. |
| Application | ELISA, Western Blot, Immunoprecipitation, Immunocytochemistry. Recommended dilutions: 1/500-1/5000. |
| Specificity | Recognizes human XPG. |
| Formulation | Liquid. Does not contain any preservative. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
XPG is a single-strand specific DNA endonuclease involved in Nucleotide Excision Repair (NER) and DNA replication stress response. It is essential for removing damaged DNA segments to maintain genomic stability. XPG acts as an endonuclease, making a single-stranded cut on the 3? side of damaged DNA during NER. It works alongside XPF-ERCC1, which makes a 5? incision, allowing removal of the damaged DNA segment. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in XPD (ERCC2) cause Xeroderma Pigmentosum (XP-D). This leads to extreme UV sensitivity, freckling, and pigmentation abnormalities.