anti-TAF7 (formerly TAFII55), mAb (2C7)

TAF7 is a transcription cofactor that is a part of the TFIID complex, which plays an essential role in RNA polymerase II-dependent transcription initiation. It contributes to the regulation of gene expression by stabilizing and assisting in the formation of the TFIID complex, which is required for initiating transcription at core promoters. TAF7 is a core subunit of the TFIID complex, which is responsible for recognizing core promoter sequences (such as the TATA box) and recruiting RNA polymerase II to initiate transcription. It is involved in the recruitment of transcription factors and coactivators that are necessary for gene-specific transcriptional activation. TAF7 plays a critical role in gene regulation during development, particularly in embryonic development and cell differentiation. Dysregulation of transcription initiation can lead to abnormal gene expression, particularly genes involved in cell proliferation, survival, and apoptosis, which may promote tumorigenesis.