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Bertin Bioreagent
anti-TIF1α, mAb (1E8)
As low as
CHF 778.00
In stock
Only %1 left
BRT-G01099-R100100 µlCHF 778.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | Transcription Intermediary Factor 1-alpha; E3 Ubiquitin-protein Ligase Trim24; Tripartite Motif-containing Protein 24; RING-type E3 Ubiquitin Transferase TIF1-alpha |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 1E8 |
| Isotype | Mouse IgG1κ |
| Source/Host | Mouse |
| Immunogen/Antigen | Recombinant protein. |
| Application | ELISA, Western Blot, Immunofluorescence. Recommended dilutions: 1/500-1/5000. |
| Specificity | Recognizes human and mouse TIF1 alpha. |
| Formulation | Liquid. Does not contain any preservative. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
TIF1α is not a direct transcription factor, but it plays a crucial role in regulating gene expression by interacting with transcriptional machinery, nuclear receptors, and chromatin-modifying complexes. It is a co-regulator of nuclear receptors like the estrogen receptor (ER), retinoic acid receptor (RAR), and glucocorticoid receptor (GR). It contains a PHD finger and bromodomain, allowing it to recognize histone modifications (e.g., methylated histone H3). It plays a role in embryonic development by regulating genes required for differentiation. In cancer, dysregulation of TIF1α can either suppress or promote tumorigenesis by altering transcription programs.