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Bertin Bioreagent
anti-TIF1β, mAb (1A9)
As low as
CHF 778.00
In stock
Only %1 left
BRT-G01100-R100100 µlCHF 778.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | Transcription Intermediary Factor 1-beta; E3 SUMO-protein ligase TRIM28; Tripartite Motif-containing Protein 28; RING-type E3 Ubiquitin Transferase TIF1-beta; KRAB-associated Protein 1; KAP-1 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 1A9 |
| Isotype | Mouse IgG2bκ |
| Source/Host | Mouse |
| Immunogen/Antigen | Recombinant mouse TIF1beta as a fusion protein. |
| Application | ELISA, Western Blot, Immunofluorescence, Immunoprecipitation. Recommended dilutions: 1/500-1/5000. |
| Specificity | Recognizes human and mouse TIF1 beta. Epitope localized between aa 123 and 834 of mouse TIF1 beta. No cross-reactivity on TIF1 alpha. |
| Formulation | Liquid. Does not contain any preservative. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
TIF1β (TRIM28/KAP1) is a critical transcriptional corepressor and chromatin regulator involved in gene silencing, development, DNA damage repair, and cancer progression. TIF1β functions mainly as a transcriptional repressor by interacting with KRAB zinc-finger proteins (KRAB-ZFPs). It recruits chromatin-modifying complexes, including histone deacetylases (HDACs) and SETDB1, leading to heterochromatin formation and gene silencing. It plays a critical role in silencing endogenous retroviruses (ERVs) and transposable elements, protecting genome stability. It binds to heterochromatin, facilitating histone H3K9 methylation, which is associated with gene repression. It is essential for early embryonic development by repressing genes that control differentiation. TIF1β is involved in the DNA damage response (DDR) by modifying chromatin structure at damage sites. TIF1β can act as both a tumor suppressor and an oncogene.