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Bertin Bioreagent
anti-TIF1γ, mAb (3E9)
As low as
CHF 778.00
In stock
Only %1 left
BRT-G01101-R100100 µlCHF 778.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | Transcription Intermediary Factor 1-gamma; E3 Ubiquitin-protein Ligase Trim33; Tripartite Motif-containing Protein 33; RING-type E3 Ubiquitin Transferase TRIM33; RET-fused Gene 7 Protein; Protein Rfg7; EC:2.3.2.27 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 3E9 |
| Isotype | Mouse IgG1κ |
| Source/Host | Mouse |
| Immunogen/Antigen | Synthetic peptide. |
| Application | ELISA, Western Blot, Immunocytochemistry. Recommended dilutions: 1/500-1/5000. |
| Specificity | Recognizes human and mouse TIF1 gamma. No cross reactivity on TIF1 alpha and TIF1 beta. |
| Formulation | Liquid. Does not contain any preservative. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
TIF1γ is a multifunctional protein involved in gene regulation, chromatin remodeling and cell signaling. It acts as a co-regulator of transcription factors, particularly in the TGF-β/SMAD signaling pathway. It promotes SMAD4 ubiquitination, preventing excessive TGF-β signaling, which is critical for controlling cell proliferation and differentiation. TIF1γ functions as a co-repressor or co-activator of transcription factors. It binds to chromatin and modifies histones, influencing gene expression. It plays a role in hematopoiesis (blood cell development) by regulating lineage-specific genes. TIF1γ acts as a tumor suppressor and helps regulate innate immunity by modulating inflammatory pathways. Altered TIF1γ function has been linked to cancers such as pancreatic, liver, and hematologic malignancies.