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Bertin Bioreagent
anti-TIF2, mAb (3C11)
As low as
664
CHF
CHF 664.00
In stock
Only %1 left
BRT-G01104-R100100 µlCHF 664.00
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| Product Details | |
|---|---|
| Synonyms | Transcriptional Intermediary Factor 2; Nuclear Receptor Coactivator 2; NCoA-2; Class E Basic Helix-loop-helix Protein 75 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 3C11 |
| Isotype | Mouse IgG1κ |
| Source/Host | Mouse |
| Immunogen/Antigen | Recombinant human TIF2. |
| Application | ELISA, Western Blot, Immunofluorescence, ChIP. Recommended dilutions: 1/500-1/5000. |
| Specificity | Recognizes human TIF2. Epitope localized between aa 624 and 869 of human TIF2. |
| Formulation | Liquid. Does not contain any preservative. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
TIF2 is a transcriptional coactivator that enhances the function of nuclear hormone receptors. It plays a key role in hormone signaling, gene regulation, and chromatin remodeling. TIF2 interacts with various steroid hormone receptors, such as estrogen receptor (ER), androgen receptor (AR), glucocorticoid receptor (GR), thyroid hormone receptor (TR) or retinoic acid receptor (RAR). It enhances transcription of hormone-responsive genes by recruiting histone acetyltransferases (HATs) like CBP/p300. TIF2 modifies chromatin to make DNA more accessible for transcription. TIF2 is involved in lipid metabolism and adipogenesis. It helps regulate genes linked to fat storage and insulin sensitivity. Overexpression of TIF2 has been linked to prostate cancer, breast cancer, and leukemia.